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194件中 121件 - 150件
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| 商品 | 説明 | 価格 |
|---|---|---|
 Epigenetics of Aging and Longevity Translational Epigenetics vol 4【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞＜em＞Epigenetics of Aging and Longevity＜/em＞ provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnessesーincluding cancer and cardiovascular, metabolic, and neurodegenerative diseasesーare explored in detail.＜/p＞ ＜p＞This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.＜/p＞ ＜ul＞ ＜li＞Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease＜/li＞ ＜li＞Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory＜/li＞ ＜li＞Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan＜/li＞ ＜/ul＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 14,830円 |
 Let Your Tears Flow: Transforming the Transgenerational Trauma of Your Family Tree Exploring Systemic Healing, Inherited Emotional Genealogy, Entanglements, Epigenetics & Body Focused Systemic Constellations【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Let Your Tears Flow provides hope for anyone frustrated with a lack of answers for their symptoms, conditions and repetitive life challenges. Do you experience unexplainable fears; feelings of grief, anger or shame; addictions; relationship challenges; anxiety or depression; burnout or chronic health conditions? These are some of the ways that descendants carry transgenerational trauma for their ancestors. This book reflects upon how to recognize the transgenerational trauma you might be carrying for your parents, grandparents and ancestors, and provides body focused ways to address it. If you repeatedly explore different medical treatments, therapies or alternative healing techniques, yet remain stuck in life in some way; there is a strong likelihood that you are entangled with someone or something in your family system that is emotionally unresolved. My family system had plenty of transgenerational trauma to address and yours might too. War, immigration, displacement, family tragedy, birth trauma, adoption, exclusion or religious persecution are some of the transgenerational trauma experiences that transmit from generation to generation. Silence is a profound carrier of transgenerational trauma in many family systems. If you know very little about your ancestors, then the transgenerational trauma has likely been silenced. Family secrets or traumatizing experiences that are silenced take on a life of their own. They live on in the unconscious body of family members waiting to be addressed. The impact on living generations becomes more powerful with each generation of silence. This book is a compilation of blog entries (aka small essays) on topics of transgenerational trauma and systemic healing. It engages with the insight that is found through systemic and family constellations, emphasizing the need for energetic body focused systemic healing approaches. It is the second in a series of books that will be made available shortly on numerous systemic healing topics. Our ancestors didn’t have access to the knowledge about systemic healing that we are developing today. What the ancestors suppressed emotionally, going on stoically as if everything was fine, may be a template for your life. Any transgenerational trauma or inherited trauma that you don’t address may be passed down to your children and grandchildren through their pre- and perinatal experiences, epigenetically, through collective memory or culturally in the cells of their body. Most of you carry either subtle or blatant unresolved family emotional wounds or trauma as energetic entanglements and it may be holding you back in life. You may be surprised to learn that you unconsciously sacrificed yourself out of love and loyalty for your greater family system to carry a wound, trauma or imbalance that needed to be acknowledged, addressed and healed. This book covers topics such as what it means to be drawn to the dead, energetic separation from the dead, when a child is born to a woman in mourning, former intimate partners, energetic impact of parent separation on children, adopted children, the death of a twin, immigration, living life fully, Eastern European family and community dynamics and epigenetics. We desire healthy emotional response patterns and ways to quickly work through our emotional issues and the issues we carry for our ancestors. This book provides examples of transgenerational trauma and systemic healing for the walking wounded, all the healers and helpers of the world, the victims and perpetrators, the colonized and colonizers, the genealogists who continue to search and the many clients and patients who go from practitioner to practitioner searching for answers. Let Your Tears Flow was written for you and I, and for our children and grandchildren.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 1,067円 |
 Epigenetics and Cancer【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic reprogramming of miRNAs and mRNAs for the prevention and/or treatment of human malignancies. It is well known that genetic aberrations, especially inherited through parents (somatic genetic alterations) contribute to the development of less than 10% of all cancer yet epigenetic alterations in genes especially through selective methylation and acetylation appears to be responsible for the development and progression of the vast majority of all cancers. Therefore, understanding the role of epigenetics in the regulation of genes especially through deregulated expression of miRNAs as presented in this book will allow scientists to devise targeted therapeutic strategies for re-expression of the lost genes or down-regulate the genes that are over-expressed in order to eradicate cancer. It is hoped that targeting epigenetics will not only target cancer cells but it will also target the tumor microenvironment (more like the entire tumor environment such as the entire host) for achieving better treatment outcomes for patients diagnosed with cancer which will lead to achieve the long-term objective for complete eradication of cancer. This book contains fifteen chapters which begins with the concept of systems and network biology for investigating the epigenetics of cancer followed by a series of articles on the role of miRNAs and their target genes in the biology of pancreatic cancer and other cancers such as breast, kidney, prostate and and colon. Since it is becoming increasingly clear that cancer stem cells (CSCs) are important in the development and progression of cancer, and CSCs are important in therapeutic resistance, treatment failure and tumor recurrence, thus the importance of CSCs and epigenetics has been highlighted by a very timely article on epigenetic variations of stem cell markers in cancer including miRNAs. Moreover, just targeting heterogeneous cancer cell populations may not be optimal to eradicate tumors and for which one must take a holistic approach for developing drugs that could also target the tumor microenvironment and tumor dormancy that are regulated through epigenetics. Keeping abreast with this thought process the concluding chapter provides a concept towards curative cancer therapy with maspin, which could be a unique window of opportunity to target tumor dormancy. Therefore, it suggest that targeting the tumor dormancy and the tumor microenvironment using novel therapeutics specifically by targeting epigenetics would become the future of medicine.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,231円 |
 Epigenetics - A Different Way of Looking at Genetics【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞This book presents epigenetics research as a new way of looking at genetics. Topics range from basic epigenetics mechanisms to development of cells and organisms and the biological basis of diseases. In addition the book focuses on immunology and the role of viruses in epigenetics. The last part of the book highlights proteins and peptides as epigenetic modulators.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 12,154円 |
 Patho-Epigenetics of Infectious Disease【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Epigenetic modification of cellular genomes is a fascinating means of regulating tissue- and cell type-specific gene expression in all developmental stages of the life of an organism. Carefully orchestrated processes, such as DNA methylation and a plenitude of specific histone modifications secure the faithful transmission of gene expression patterns to progeny cells. Upon chronic infection, the epigenetic cellular balance can become disrupted and, in the long run, through the epigenetic reprogramming of host cell genomes, contribute to the malignant conversion of formerly healthy cells, in many cases preceded by the establishment of an epigenetic field of cancerization. The present volume undertakes to highlight the interactions of infectious pathogens and their effector molecules with the epigenetic regulatory machinery of the cell. Clearly, the recent take-off of epigenetics research did not leave Research on Infectious Diseases and Infection-Associated Cancer untouched. This resulted in a great many of clinically relevant data on understanding the molecular mechanisms of chronic infectious disease. Infectious pathogen- and disease-specific epigenetic alterations are already being used for the early detection of malignant disease and for the prediction of chemotherapy resistance or response to treatment.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 12,154円 |
 Epigenetics Territory and Cancer【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthropology’. Translating multi-disciplinary research into therapeutic design is at the core of this book. Readers may explore how cancer management involves unmasking the involved networks and the interactive status of different genes to achieve the appropriate methylome based therapy. Early chapters explore fundamental aspects and brain tumours, whilst later chapters investigate breast cancer and various other cancers, and the final chapter presents an evolutionary insight in cancer epigenetics, considering that the epigene is beyond DNA methylation, RNA interference and histone modification in cancer development. This book will be of interest to researchers in different medical and scientific fields, including clinical management (diagnosis, prognosis, prediction, prevention, and guidelines), genetic education, nutrition and nutrigenomics, industrial chemistry, and drug innovation. Because of the unique bridging between science and medicine this book will also be useful as an educational and translational research package.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,231円 |
 Nutrition, Exercise and Epigenetics: Ageing Interventions【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena.＜/p＞ ＜p＞Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3); epigenetic modification of gene expression by exercise (Chapter 5); the role of functional foods and their bioactive components in bone health (Chapter 8); and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 14,765円 |
 Epigenetics, Brain and Behavior【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,231円 |
 Patho-Epigenetics of Disease【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences.＜/p＞ ＜p＞Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity.＜/p＞ ＜p＞An alternative system of ＜strong＞epigenetic memory＜/strong＞, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression ＜em＞via＜/em＞ modification of histone tails.＜/p＞ ＜p＞The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of ＜strong＞epigenetic alterations＜/strong＞ in ＜strong＞malignant tumors＜/strong＞. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that ＜strong＞epigenetic dysregulation＜/strong＞ forms the basis of ＜strong＞a wide spectrum of humandiseases＜/strong＞.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,231円 |
 Environmental Epigenomics in Health and Disease Epigenetics and Disease Origins【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 24,309円 |
 Epigenetics, Energy Balance, and Cancer【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞This volume of ＜em＞Energy Balance and Cancer＜/em＞ provides state-of-the-art descriptions of the rapidly evolving science of epigenetics and how it may explain mechanisms by which alterations in energy balance such as obesity and physical activity may impact cancer. In addition to chapters explaining the processes mediating epigenetic regulation, the volume contains a series of chapters explaining how environmental influences including early life events, nutrition, exercise and microbiota may induce epigenetic changes that can affect carcinogenesis. The following chapters describe epigenetic relations of energy balance to cancer in distinct organ systems including esophagus, colon, prostate and breast. ＜em＞Epigenetics, Energy Balance and Cancer＜/em＞ provides a valuable resource for students, research investigators and clinicians seeking to better understand these processes as well as a basis for novel translational and transdisciplinary approaches to further elucidate these processes and develop preventive and therapeutic strategies.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,231円 |
 Epigenetics and Neuroendocrinology Clinical Focus on Psychiatry, Volume 2【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system (CNS) and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,231円 |
 Epigenetics of Aging【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research.＜/p＞ ＜p＞The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins.＜/p＞ ＜p＞Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,231円 |
 Epigenetics and Disease Pharmaceutical Opportunities【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 24,309円 |
 Epigenetics: Development and Disease【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies. This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 36,464円 |
 Epigenetics and Human Reproduction【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 24,309円 |
 Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications Transcriptional Regulation and Chromatin Remodelling in Plants【電子書籍】[ Ra?l Alvarez-Venegas ] 楽天Kobo電子書籍ストア | ＜p＞Over the past decades, chromatin remodelling has emerged as an important regulator of gene expression and plant defense. This book provides a detailed understanding of the epigenetic mechanisms involved in plants of agronomic importance. The information presented here is significant because it is expected to provide the knowledge needed to develop in the future treatments to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases and to increase crop productivity. New approaches of this kind and the development of new technologies will certainly increase our knowledge of currently known post-translational modifications and facilitate the understanding of their roles in, for example, host-pathogen interactions and crop productivity. Furthermore, we provide important insight on how the plant epigenome changes in response to developmental or environmental stimuli, how chromatin modifications are established and maintained, to which degree they are used throughout the genome, and how chromatin modifications influence each another.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 14,765円 |
 Environmental Epigenomics in Health and Disease Epigenetics and Complex Diseases【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this two volume book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome. Consequently, epigenetic research promises to markedly improve our ability to diagnosis, prevent, and treat the pathological conditions of humans; however, it also introduces unique legal and ethical issues. This volume highlights the correlation between environmental factors and complex diseases, such as autism, addiction, neurological diseases, diabetes, obesity and cancer. It concludes with a chapter on legal and ethical implications of epigenetics.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 24,309円 |
 Brain, Behavior and Epigenetics【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 24,309円 |
 Environmental Epigenetics【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases.＜/p＞ ＜p＞＜em＞Environmental Epigenetics＜/em＞ imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology.＜/p＞ ＜p＞This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.＜/p＞ ＜p＞＜em＞Environmental Epigenetics＜/em＞ imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology.＜/p＞ ＜p＞This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 14,585円 |
 Epigenetics in Cardiac Disease【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,231円 |
 Connect With Your Ancestors: Transforming the Transgenerational Trauma of Your Family Tree Exploring Systemic Healing, Inherited Emotional Genealogy, Entanglements, Epigenetics and Body Focused Systemic Constellations【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Connect With Your Ancestors provides hope for anyone frustrated with a lack of answers for their symptoms, conditions and repetitive life challenges. Do you experience unexplainable fears; feelings of grief, anger or shame; addictions; relationship challenges; anxiety or depression; burnout or chronic health conditions? These are some of the ways that descendants carry transgenerational trauma for their ancestors. This book reflects upon how to recognize the transgenerational trauma you might be carrying for your parents, grandparents and ancestors, and provides body focused ways to address it. If you repeatedly explore different medical treatments, therapies or alternative healing techniques, yet remain stuck in life in some way; there is a strong likelihood that you are entangled with someone or something in your family system that is emotionally unresolved. My family system had plenty of transgenerational trauma to address and yours might too. War, immigration, displacement, family tragedy, birth trauma, adoption, exclusion or religious persecution are some of the transgenerational trauma experiences that transmit from generation to generation. Silence is a profound carrier of transgenerational trauma in many family systems. If you know very little about your ancestors than the transgenerational trauma has likely been silenced. Family secrets or traumatizing experiences that are silenced take on a life of their own. They live on in the unconscious body of family members waiting to be addressed. The impact on living generations becomes more powerful with each generation of silence. This book is a compilation of blog entries (aka small essays) on topics of transgenerational trauma and systemic healing. It engages with the insight that is found through systemic and family constellations, emphasizing the need for energetic body focused systemic healing approaches. It is the first in a series of books that will be made available shortly on numerous systemic healing topics. Our ancestors didn’t have access to the knowledge about systemic healing that we are developing today. What the ancestors suppressed emotionally, going on stoically as if everything was fine, may be a template for your life. Any transgenerational trauma or inherited trauma that you don’t address may be passed down to your children and grandchildren through their pre- and perinatal experiences, epigenetically, through collective memory or culturally in the cells of their body. Most of you carry either subtle or blatant unresolved family emotional wounds or trauma as energetic entanglements and it may be holding you back in life. You may be surprised to learn that you unconsciously sacrificed yourself out of love and loyalty for your greater family system to carry a wound, trauma or imbalance that needed to be acknowledged, addressed and healed. This book covers topics such as systemic healing, emotional entanglement, radical inclusion, emotional wounds for men, relationships with father, chronic illness, belonging in the family, ungrounded fears, living in agency, give and take in relationships, intimate relationships and body focused ritual practices for healing. In the rapidly changing technological world we live in today, our mind, body, heart and spirit are struggling to keep up with the wild pace. We desire healthy emotional response patterns and ways to quickly work through our emotional issues and the issues we carry for our ancestors. This book provides examples of transgenerational trauma and systemic healing for the walking wounded, all the healers and helpers of the world, the victims and perpetrators, the colonized and colonizers, the genealogists who continue to search and the many clients and patients who go from practitioner to practitioner searching for answers. Connect With Your Ancestors was written for you and I, and for our children and grandchildren.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 1,067円 |
 Epigenetics.The DNA of the pregnant mother How to Strenght Your Genes and Create Super Babies Conceived Naturally or by Egg Donation【電子書籍】[ Sara Toledo ] 楽天Kobo電子書籍ストア | ＜p＞"Your maternal womb modifies the genetics of your baby conceived naturally or donated by another woman, as in a case of a lesbian couple (who'd prefer to use the ROPA method) or with an unrelated surrogate.＜br /＞ With healthy habits maintained over time we can optimise the inheritance we receive from our parents and grandmothers and pass it on to our grandchildren. "＜/p＞ ＜p＞I wrote "Epigenetics. The DNA of the pregnant mother" mainly thinking of all those women who assume that they must to give up all genetics to become a mother throught an egg/embryo donation, or thinking of doctors who don't remember that a woman is a unique human being, a life recipient and donor. AND GENETICS.＜/p＞ ＜p＞Remember that you don't need to get a kindle e-reader to enjoy ebooks.You can use any Computer,laptot or cell phone to read e-books at no extra-cost.＜/p＞ ＜ol＞ ＜li＞INTRODUCTION＜br /＞ What is Epigenetics?＜br /＞ Beginning of epigenetic surveys: 3rd generation offspring of pregnant women in time of famine (World War II: Holland 1944/45)＜br /＞ The influential environment＜/li＞ ＜/ol＞ ＜p＞2.WILL MY GENES SHOW UP?＜br /＞ Genetic heritage is not always assured＜br /＞ Phenotype (physical traits)＜br /＞ Intelligence (high levels)＜br /＞ Diseases＜br /＞ Epimutations＜/p＞ ＜p＞3.DETRIMENTAL EPIGENETIC MEMORY＜br /＞ Cellular sensitivity to harmful environmental factors＜br /＞ A) During the embryonic stage＜br /＞ ?High stress or violent situations＜br /＞ ?Malnutrition of the mother＜br /＞ ?Exposure to tobacco during pregnancy＜br /＞ ?Intake of alcohol＜br /＞ B) During childhood and puberty＜br /＞ ?Missing figures for secure attachment＜br /＞ ?Emotional status of parents＜br /＞ ?Hereditary Poverty＜/p＞ ＜p＞4.GENES FOR HEALTH＜br /＞ From healthy genes to disease genes＜br /＞ Nutrition and maternal digestion＜br /＞ 10 Daily routines that can reinterpret the DNA program of the embryo in the mother's womb＜br /＞ ?Physical contact＜br /＞ ?Healthy nutrition and intellectual performance＜br /＞ ?Positive experiences＜br /＞ ?Reduce fear or chronic stress＜br /＞ ?The game＜br /＞ ?Positive attitude＜br /＞ ?Moderate physical exercise＜br /＞ ?Secure attachment＜br /＞ ?Voice and language＜br /＞ ?Give and let them feed us＜br /＞ Reproductive health＜br /＞ A)Nutrients＜br /＞ ?Mineral Zinc and Vitamin B6＜br /＞ ?Omega 3 and 6 fatty acids＜br /＞ ?Vitamin C and E＜br /＞ ?Vitamin A＜br /＞ ?Selenium＜br /＞ B)Antinutrients＜br /＞ ?SugarAlcohol＜br /＞ ?Tobacco＜br /＞ ?Toxic metals＜br /＞ ?Birth control pill＜br /＞ ?Exposure to environmental chemicals＜br /＞ ?Homocysitein＜br /＞ ?Stress＜br /＞ ?Sexually transmitted diseases and bacterial infections＜/p＞ ＜p＞5.EPIGENETICS IN ASSISTED REPRODUCTION＜br /＞ At Square One: I am infertile＜br /＞ Active reception of fertilized eggs: not passive＜br /＞ The pregnant mother influence: Exchange between endometrium and the embryo＜br /＞ Is it possible to transmit physical features of the pregnant mother?＜br /＞ Graphic sequence of DNA modification by the pregnant mother＜br /＞ Similar? No coincidence!＜br /＞ The personality of the children is not determined by the donated eggs＜br /＞ Telling or keeping quiet in family＜br /＞ Anonymous Donor Vs. Known donor＜br /＞ Epigenetic footprint of in vitro treatments in embryos＜/p＞ ＜ol start="6"＞ ＜li＞ROPA METHOD (FERTILIZED EGG TRANSFER IN FEMALE COUPLES)＜br /＞ ROPA Method: An Active Role in In Vitro Fertilization and Gestation for Both Women＜br /＞ Maternal instincts in female couples＜br /＞ Homoparental environment: Good gestational model＜br /＞ 7.CONCLUSIONS＜br /＞ 8.BIBLIOGRAPHY＜/li＞ ＜/ol＞ ＜p＞Hope to hear from you soon.＜/p＞ ＜p＞By Sara Toledo.Madrid 2017＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 538円 |
 Insect Epigenetics【電子書籍】[ Russell Jurenka ] 楽天Kobo電子書籍ストア | ＜p＞＜em＞Insect Epigenetics, Volume 53＜/em＞ provides readers with the latest interdisciplinary reviews on the topic. Updated chapters in this new release include Epigenetics in insects: Mechanisms, ecological outcomes, and evolutionary consequences, Nutrition and epigenetic change in insects, microRNAs in Drosophila insulin regulation, Epigenetic regulation of longevity in insects, Epigenetic influences on diapause, the Impact of parasites on epigenetics of their insect hosts, The molecular physiology of locust swarming behavior, The future of environmental epigenetics: insights using the clonal water-flea model, and. Epigenetics ? A hidden target of insecticides.＜/p＞ ＜p＞Led by volume editor Heleen Verlinden, this is an essential reference source for entomologists, zoologists, geneticists and insect chemists.＜/p＞ ＜ul＞ ＜li＞Presents a comprehensive overview of environmental impacts on insect epigenetics＜/li＞ ＜li＞Written by leaders in their respective areas of research＜/li＞ ＜li＞Ideal resource for entomologists, zoologists, geneticists and insect chemists＜/li＞ ＜/ul＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 19,307円 |
 Handbook of Epigenetics The New Molecular and Medical Genetics【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞＜em＞Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition,＜/em＞ provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging.＜/p＞ ＜p＞The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders.＜/p＞ ＜ul＞ ＜li＞Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field＜/li＞ ＜li＞Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine＜/li＞ ＜li＞Written at a verbal and technical level that can be understood by scientists and college students＜/li＞ ＜li＞Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials＜/li＞ ＜/ul＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 19,773円 |
 Epigenetics of Infectious Diseases【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions ? the latter frequently induced by pathogens ? plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,231円 |
 Gene Regulation, Epigenetics and Hormone Signaling【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 42,343円 |
 Enzymes of Epigenetics【電子書籍】[ Ronen Marmorstein ] 楽天Kobo電子書籍ストア | ＜p＞＜em＞Enzymes of Epigenetics＜/em＞, one of two new volumes in the ＜em＞Methods in Enzymology＜/em＞ series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.＜/p＞ ＜p＞This volume covers research methods that are employed to study epigenetic regulation and includes structural, biochemical, molecular, biological, cellular, computational, and systems approaches.＜/p＞ ＜p＞Topics include chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies and small molecule epigenetic regulators, and biological connections＜/p＞ ＜ul＞ ＜li＞Continues the legacy of this premier serial with quality chapters authored by leaders in the field＜/li＞ ＜li＞Contains two new volumes covering research methods in enzymes of epigenetics＜/li＞ ＜li＞Covers topics such as chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies and small molecule epigenetic regulators and biological connections＜/li＞ ＜/ul＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 23,145円 |
 Plant Epigenetics【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞This book presents, in 26 chapters, the status quo in epigenomic profiling. It discusses how functional information can be indirectly inferred and describes the new approaches that promise functional answers, collectively referred to as epigenome editing. It highlights the latest important advances in our understanding of the functions of plant epigenomics and new technologies for the study of epigenomic marks and mechanisms in plants. Topics include the deposition or removal of chromatin modifications and histone variants, the role of epigenetics in development and response to environmental signals, natural variation and ecology, as well as applications for epigenetics in crop improvement. Discussing areas ranging from the complex regulation of stress and heterosis to the precise mechanisms of DNA and histone modifications, it presents breakthroughs in our understanding of complex phenotypic phenomena.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 24,309円 |
 Epigenetics and Systems Biology【電子書籍】[ Leonie Ringrose ] 楽天Kobo電子書籍ストア | ＜p＞＜em＞Epigenetics and Systems Biology＜/em＞ highlights the need for collaboration between experiments and theoretical modeling that is required for successful application of systems biology in epigenetics studies.＜/p＞ ＜p＞This book breaks down the obstacles which exist between systems biology and epigenetics researchers due to information barriers and segmented research, giving real-life examples of successful combinations of systems biology and epigenetics experiments.＜/p＞ ＜p＞Each section covers one type of modeling and one set of epigenetic questions on which said models have been successfully applied. In addition, the book highlights how modeling and systems biology relate to studies of RNA, DNA, and genome instability, mechanisms of DNA damage signaling and repair, and the effect of the environment on genome stability.＜/p＞ ＜ul＞ ＜li＞Presents original research in a wider perspective to reveal potential for synergies between the two fields of study＜/li＞ ＜li＞Provides the latest experiments in primary literature for the modeling audience＜/li＞ ＜li＞Includes chapters written by experts in systems biology and epigenetics who have vast experience studying clinical applications＜/li＞ ＜/ul＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 14,830円 |