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Clinical Mitochondrial Medicine【電子書籍】楽天Kobo電子書籍ストア	＜p＞Mitochondrial disorders are a highly diverse group of conditions that can affect almost every major system in the human body, often mimicking common disorders. This clinical variety often results in prolonged and often dangerous, diagnostic delays. This textbook provides a practical framework, to enable rapid identification, investigation, and treatment of mitochondrial disorders across the spectrum of clinical practice. Clinically relevant and comprehensive, this textbook employs a system- and case-based approach for practitioners of all levels. It focuses on major phenotypic features, syndromes and management relevant for clinical practice, within a broad overview of the field. This interactive book supports readers with knowledge distilled from over 20 internationally recognized, mitochondrial experts.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	8,093円
Mitochondrial Diseases【電子書籍】[ Wiley ] 楽天Kobo電子書籍ストア	＜p＞This collection of reviews and protocols provides the reader with an introduction to the current state of knowledge on how various diseases are related to mitochondrial dysfunction. Mitochondria contain their own genome, a small, circular double-stranded DNA (mtDNA), and alterations in mtDNA may play an important role in the multistep carcinogenesis of at least some types of human cancer. In addition to mutations of mtDNA, many mitochondrial syndromes are due to abnormalities in nuclear genes related to oxidative phosphorylation (OXPHOS). Mitochondrial tRNA (＜em＞MTT＜/em＞) gene mutations are an important cause of human morbidity and are associated with a wide range of pathology, from isolated organ?]specific diseases such as myopathy or hearing loss, to multisystem disorders with encephalopathy, gastrointestinal dysmotility, and life?]threatening cardiomyopathy. The relationship of the mitochondrion organelle to aging and longevity is also discussed.＜/p＞＜p＞Laboratory protocols describe methodology to characterize mtDNA heteroplasmy by parallel sequencing. Each eukaryotic cell contains hundreds of mitochondria with hundreds of mitochondria genomes. Mutant and wild-type mtDNA may co-exist as heteroplasmy, and cause human disease. The purpose of this protocol is to simultaneously determine mtDNA sequence and quantify the heteroplasmic level. Another protocol describes procedures for obtaining tissue sections and cell material suitable for histological evaluation of OXPHOS activity and integrity and immunodetection of the complexes in tissue from patients suspected of mitochondrial disease. Emphasis lies on the diagnostic potential of these techniques to differentiate mtDNA from nuclear mutations.＜/p＞＜p＞This e-book ー a curated collection from eLS, WIREs, and Current Protocols ー offers a fantastic introduction to the field of mitochondrial diseases for students or interdisciplinary collaborators.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	4,580円
Mitochondrial Metabolism An Approach to Disease Management【電子書籍】楽天Kobo電子書籍ストア	＜p＞Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. - Details the significant role of mitochondria in chronic diseases - Presents new insights on the targeting of mitochondria for therapeutic purposes - Includes updated results on mitotherapy and other mitochondria-oriented therapies＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	15,861円
Mitochondrial Disorders in Neurology Butterworth-Heinemann International Medical Reviews【電子書籍】楽天Kobo電子書籍ストア	＜p＞Mitochondrial Disorders in Neurology provides an overview of mitochondrial diseases. This book discusses the effects of mitochondrial dysfunction based on the relevant biochemistry and molecular genetics. The abnormal muscle and mitochondrial morphology in a variety of clinical presentations from isolated ophthalmoplegia to severe encephalopathy are also elaborated. This text likewise deliberates Leber's hereditary optic neuropathy, neurodegenerative disorders, and respiratory chain defects. Other topics covered include mitochondrial DNA and the genetics of mitochondrial disease; cytochrome oxidase deficiency; use of tissue culture in the diagnosis of mitochondrial disease; and advances in mitochondrial genetics. This publication is a good source for clinicians and students concerned with the defective mitochondrial function.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	7,714円
Mitochondrial Dysfunction and Nanotherapeutics Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine【電子書籍】楽天Kobo電子書籍ストア	＜p＞Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies. - Contains detailed information on mitochondrial dysfunction - Reviews our current understanding of the role of mitochondria in aging - Includes coverage of specific conditions, including sports and affective disorders, among others - Discusses mitochondria targeted delivery of therapeutic compounds＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	18,504円
Mitochondrial Physiology and Vegetal Molecules Therapeutic Potential of Natural Compounds on Mitochondrial Health【電子書籍】楽天Kobo電子書籍ストア	＜p＞Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health provides a comprehensive overview of mitochondrial physiology throughout the human life span, as well as the effect of molecules of vegetal origin on mitochondrial health. The editor has lined up a team of worldwide experts to cover the most exciting and high-impact advancements of research in this area. This book is structured into two parts that provide a balance of both foundational and applied content. Part I provides an overview of mitochondrial physiology including its structure, dynamics, biogenesis, membranes, DNA transcription, and translation in the mitochondria. Part I also covers other themes such as apoptosis. Part II then covers the effect of specific vegetable-derived molecules on mitochondrial health, including anthocyanins, caffeine, cannabinoids, carnosic and rosmarinic acids, citrus flavonoids, polyphenols, pterostilbene, resveratrol, and sulforaphane, among others. Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health is a complete resource for researchers in this exciting field. Its comprehensive coverage makes it particularly interesting to bioscience researchers willing to understand the foundations of mitochondrial physiology throughout the human life span. Clinician researchers, MDs, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the health effects of vegetal origin molecules on the organelle. - Contains detailed information on plant products and their effect on mitochondria - Proposes therapies and reviews mechanisms of absorption at the cellular level - Discusses the limited bioavailability of plant molecules/compounds in the human organism - Includes coverage of specific conditions such as Sports and affective disorders, among others - Presents the protective effects of plant products in mitochondrial health through all stages of life＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	15,861円
Mitochondria in Obesity and Type 2 Diabetes Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases【電子書籍】楽天Kobo電子書籍ストア	＜p＞Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. - Synthesizes actual knowledge on mitochondrial function - Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes - Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression - Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	15,861円
Mitochondria Diet A 3-Week Plan to Managing Mitochondrial Dysfunction Through Nutrition【電子書籍】[ Jeffrey Winzant ] 楽天Kobo電子書籍ストア	＜h2＞Did you know that mitochondrial health is an essential key to longevity and overall well-being?＜/h2＞＜p＞Mitochondria are often overlooked in the body's complex cellular structure. They may not get as much attention as the brain or heart, but they are integral to overall health just like any other organ, and your health can be affected by the inner workings of these tiny organelles.＜/p＞＜p＞For example, when your cells don't use energy properly from food because they cannot metabolize glucose (a type of sugar), your mitochondria cellular structures stop functioning efficiently, resulting in insulin resistance as well-both upstream triggers for health problems like cardiovascular disease, diabetes, cancer, Alzheimer's Disease, Parkinson's Disease and much more.＜/p＞＜p＞Fortunately, there are many steps that you can take to manage these mitochondrial dysfunctions through nutrition. That's why we have outlined a 3-weeks meal plan designed with your mitochondria in mind.＜/p＞＜p＞First things first, it's a good idea to understand what mitochondria are and why they are vital for optimal health. Stay tuned for a deep dive into what they do, why you should care about them, and how you can take better care of them through nutrition.＜/p＞＜h2＞＜/h2＞＜h2＞In this guide, you'll discover:＜/h2＞＜ul＞＜li＞What are mitochondria＜/li＞＜li＞Diet tips to help improve your mitochondria function＜/li＞＜li＞Symptoms you can tell your cellular structures are not working properly＜/li＞＜li＞A seven-day weekly plan＜/li＞＜li＞Sample recipes to follow＜/li＞＜/ul＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	703円
Mitochondrial Inhibitors and Neurodegenerative Disorders【電子書籍】楽天Kobo電子書籍ストア	＜p＞Mitochondria have long been the Rodney Dangerfield of cellular organelles. Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function. The extraordinary dependence of cells on the energy provided by mito chondrial oxidative metabolism of glucose, especially through critical organs such as the heart and brain, is underlined by the fatal consequences of toxins that interfere with the mitochondrial electron transport system. Consistent with their ancestry, the mitochondria have their own DNA that encodes many but not all of their proteins. The mitochon dria and their genes come from the mother via the ovum since sperm do not possess mitochondria. This extranuclear form of inheritance derived exclusively from the female side has proven to be a powerful tool for tracing the evolution by the number of base substitutions in mtDNA. That mitochondrial gene mutations might be a source of human dis ease became evident a decade ago with the characterization of a group of multisystem disorders, typically involving the nervous system, which are transmitted from mother to child. Specific point mutations in mtDNA have been associated with the different syndromes.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	18,231円
Mitochondrial Diseases【電子書籍】[ Rita Horvath ] 楽天Kobo電子書籍ストア	＜p＞Mitochondrial Diseases, Volume 194 presents the most common clinical manifestations, providing an up-to-date summaries on the clinical presentations, diagnostic processes, genetic counseling and treatment options in mitochondrial diseases. Contents include specialist biochemical analyses and targeted molecular genetic testing, as well as first-line genome-wide sequencing to accelerate speed of diagnosis while avoiding time-consuming, expensive and invasive investigations. Establishing a genetic diagnosis allows patients with mitochondrial diseases to have reproductive options, all of which are covered within.This book is intended for neurologists to help them recognize and manage patients with mitochondrial diseases. - Examines the pathophysiology of mitochondrial diseases and disorders - Focuses on neurological symptoms of mitochondrial diseases - Presents myopathies, neuropathies, epilepsy, ataxia, paraplegias, and more - Covers histology, metabolism, genetic, and neuroimaging diagnostics - Summarizes both available and emerging therapies - Includes clinical trials, the use of biomarkers and reproductive options＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	29,077円
Mitochondrial Medicine A Primer for Health Care Providers and Translational Researchers【電子書籍】[ Pankaj Prasun ] 楽天Kobo電子書籍ストア	＜p＞Mitochondrial Medicine: A Primer for Health Care Providers and Translational Researchers is an applied, holistic resource that addresses the evolving and multidisciplinary area of mitochondrial disease. The book discusses the fundamentals of mitochondrial medicine in humans, as well as the pathophysiology, diagnosis and treatment of mitochondrial diseases. Three all-inclusive sections examine the role of mitochondria in common medical conditions, such as diabetes, heart failure and the full range of inherited mitochondrial diseases. Sections cover the genetic and biochemical basis of both mitochondrial DNA deletion syndromes and point mutation syndromes, their clinical presentation, treatment plans, genetic counseling, prenatal testing, and ongoing research. While providing a solid foundation in its topic area, each chapter in the book is written in an accessible format with illustrative case studies, thus making it a quick bedside or clinical laboratory reference. - Includes a basic introduction to mitochondria and their misfunctions in human disease - Presents current practice and research in mitochondrial medicine, with an emphasis on clinical presentation, diagnosis, treatment, genetic counseling and prenatal testing - Features short, accessible chapters with illustrative case studies for quick reference - Provides thorough coverage of inherited mitochondrial disorders, as well as the role of mitochondria in common medical conditions＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	13,746円
Mitochondrial Disorders Caused by Nuclear Genes【電子書籍】楽天Kobo電子書籍ストア	＜p＞Mitochondrial cytopathies are mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation. Mitochondrial respiratory chain disorders (RCD) are a group of genetically and clinically heterogeneous diseases, due to the fact that protein components of the respiratory chain are encoded by both mitochondrial and nuclear genomes and are essential in all cells. In addition, the biogenesis, structure and function of mitochondria, including DNA replication, transcription, and translation, all require nuclear encoded genes. Since mitochondria are present in every cell, every tissue, mitochondrial disorder usually affects multiple organs.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	18,231円
The Mitochondrial Curiosities of Marcels 1 to 19【電子書籍】[ Jocelyn Brown ] 楽天Kobo電子書籍ストア	＜p＞＜em＞Her hands lay inert and upturned on her lap ? probably stunned, she thinks, by the hideousness of the skirt underneath them. Centre seam puckered, zipper mangled, it's handmade in a way that makes people say, 'Did you sew that yourself?' when they mean, 'How can you wear that thing?' But she made it the day after he died, and she talked to him in her head the whole time. Which is why it looks like hell and why she had to wear it anyway.＜/em＞＜/p＞＜p＞Biology is not Dree's thing. Equally heinous are English, Social Studies, her sister and mother, not to mention Edmonton in general. Toronto is where she belongs ? specifically the upcoming Renegade Craft Fair.＜/p＞＜p＞Mercifully, escape is imminent: on her fifteenth birthday, she will get the special fund her father promised, and the day after that, she'll be on WestJet Flight 233 to Toronto. Instead, her dad has a fatal heart attack, and all she finds are clues leading to the ominous Alberta Psychiatric Hospital where her parents once worked.＜/p＞＜p＞Along the way: two fires, a family scandal, nineteen sassy sock creatures named Marcel, a new friend, a mystery, a stepmother who's maybe sympathetic after all, the unceasing misery of school and the search for a proper way to grieve a father.＜/p＞＜p＞Instructions for renegade crafts and associated illustrations included.＜/p＞＜p＞‘Every now and then, a novel that is as solid as steel lands in readers' hands. A novel that needs the right proportion of its own hardening agents to deliver on the page. ＜em＞The Mitochondrial Curiosities of Marcels 1-19＜/em＞ is such a book … Brown's prose is astonishing.’＜/p＞＜p＞＜em＞Vancouver Sun＜/em＞＜/p＞＜p＞‘In this debut … Jocelyn Brown transcends … genre with a novel of depth and texture, rich with incident and very contemporary dialogue. She takes her readers deep into the complicated psyche of her narrator and heroine (yes, that's the right word), which is, as it turns out, exactly where her readers will want to be, richocheting from one OMG to another.’＜/p＞＜p＞? ＜em＞Globe and Mail＜/em＞＜/p＞＜p＞'This novel is about as strangely and intricately knotted as one of Dree's craft creations, and as hilariously fascinating.'＜/p＞＜p＞?＜em＞Quill and Quire＜/em＞＜/p＞＜p＞‘Brown’s complex characters, unusual narrative style and fabulously quirky dialogue make this a fun book with layer after layer to uncover.’＜/p＞＜p＞? ＜em＞Geist＜/em＞ Magazine＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	1,320円
Mitochondrial Diseases Theory, Diagnosis and Therapy【電子書籍】楽天Kobo電子書籍ストア	＜p＞Mitochondrial diseases comprise a clinically and genetically heterogeneous group of rare disorders that may affect virtually any system of the body at any age. Due to their complexity, understanding and diagnosing these diseases requires a multidisciplinary approach.＜/p＞＜p＞This book provides an update on the major features of human mitochondrial diseases: genetic bases, pathophysiology, diagnosis, and treatment, and of the new technologies involved in the diagnosis and on the characterization of patients. The 11 chapters examine the unique complex interactions between the mitochondrial and the nuclear genomes involved in the biogenesis and the regulation of the mitochondrial respiratory chain, and their relevance to human disease. We discuss the traditional biochemical and genetic approaches, as well as the new omic technologies, and the cellular and animal models used in mitochondrial research. The last chapter is dedicated to the current treatment options.＜/p＞＜p＞Authors are worldwide experts in these fields and integrate expertise in both basic science and clinical research.＜/p＞＜p＞This book is particularly important for both scientists and clinicians interested in the diagnosis and treatment of these diseases.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	17,016円
Mitochondrial DNA and Diseases【電子書籍】楽天Kobo電子書籍ストア	＜p＞The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinicalstudents and researchers in the field of mtDNA?associated diseases.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	18,231円
Mitochondrial Medicine Volume 2: Assessing Mitochondria【電子書籍】楽天Kobo電子書籍ストア	＜p＞This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume II guides readers through chapters on mitochondrial dysfunction, functional’ mitochondria, mitochondrial retrograde, mitochondrial dNTP pool quantification, mitochondrial ADP-ribosylation, blue-native gel approach, 3D optical cryo-imaging method, mitochondrial ATP and ROS production, protocol for untargeted metabolomic analysis, and methods for analysis of nitrotyrosine-containing proteins. Written in the highly successful ＜em＞Methods in Molecular Biology＜/em＞ series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls.＜/p＞＜p＞Authoritative and accessible, ＜em＞Mitochondrial Medicine, Second Edition, Volume 2: Assessing Mitochondria＜/em＞ aims to be acomprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	14,585円
Mitochondrial Biology and Experimental Therapeutics【電子書籍】楽天Kobo電子書籍ストア	＜p＞This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	21,878円
Mitochondrial Genetics and Cancer【電子書籍】[ Gabriel D. Dakubo ] 楽天Kobo電子書籍ストア	＜p＞With very few exceptions, eukaryotic cells possess two interdependent genomes, chromosomal and extra-chromosomal. Over the past several decades, cancer - search has focused primarily on deciphering the intricate alterations in the chro- somal genome, with until recently, very little attention to its cytoplasmic counterpart. In spite of the enormous complexity of the nuclear genome, which we now fully appreciate after completion of the human genome project, the efforts of cancer researchers are commendable in terms of the tremendous gains made in unraveling the numerous genetic changes in cancer. These changes include d- coveries of tumor suppressor genes, oncogenes, and caretaker genes that are often mutated in cancer. Recent studies of genomic pro?les are uncovering even more altered and mutated genes in cancer. Besides these ?ndings, several therapeutic targets for chemotherapy are currently made from studies of altered nuclear genetic pathways. Inspite of all these positive efforts, the war on cancer, declared in 1971 by Richard Nixon, is far from being worn. Indeed, the failure of chemotherapy is obvious to clinicians, oncologists, and their patients alike. Moreover, the global incidence and prevalence of cancer continue to rise. What are we missing? Which direction should we be taking? Of course, modern integrated nuclear genomics, proteomics, and metabolomics should provide important clues to carcinogenesis, but the contribution of cytoplasmic genetic alterations to carcinogenesis cannot be neglected.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	24,309円
Mitochondrial Neuropathies【電子書籍】[ Nigel Calcutt ] 楽天Kobo電子書籍ストア	＜p＞Mitochondrial Neuropathies, Volume 146, brings together experts in a range of diseases that damage the nervous system to present the role of mitochondrial dysfunction in their particular field, with this new release focusing on Mitochondrial dysfunction in Alzheimer's Disease, HIV and the mitochondrial: immune interface in the CNS, The Impact of mitochondrial damage in HIV-induced peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of chemotherapy-induced peripheral neuropathy, Disorders of mitochondrial biogenesis in peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of diabetic neuropathy, Manipulating mitochondria to treat peripheral neuropathy, and DCA therapy - the yin and yang of mitochondrial activation. - Contains contributions from a diverse group of experts - Presents a timely resource that brings together different fields to highlight a common pathogenic mechanism - Focuses on the role of mitochondria in diverse neuropathies＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	22,205円
Mitochondrial Disease Genes Compendium From Genes to Clinical Manifestations【電子書籍】楽天Kobo電子書籍ストア	＜p＞The field of Mitochondrial Medicine has been dominated by symptom constellation-based diagnostic categorization since the first clinical syndrome was described three decades ago. Now, as rapidly expanding knowledge has revealed that mitochondrial diseases may result from several hundred distinct gene disorders with extensive clinical and mutation heterogeneity, the most useful guide for clinical care and research embraces a gene-centric approach to each individual's disorder. Together with international colleagues, Dr. Marni Falk has developed the Mitochondrial Disease Sequence Data Resource (MSeqDR), an online, community curated, centralized data resource of mitochondrial disease data from a genomic perspective. Here, in the Mitochondrial Disease Genes Compendium, Dr. Marni Falk and a team of international experts have built off their work on MSeqDR to provide an all-in-one, readily accessible, and easy-to-use at point of care reference on 256 mitochondrial disease genes from a gene-based perspective. In this book, clinicians and researchers will find a complete overview of mitochondrial disease genes relevant across all specialties, cataloging and building context around clinical features and the genetic basis of each condition. Within, each "gene page" offers an in-depth, referenced view of the relevant clinical disease spectrum, including gene and protein descriptions, year discovered, inheritance pattern(s), age ranges affected, major clinical features and severity range, clinical pearls, known therapies, available support groups, animal models, and gene-specific basic, translational, or clinical research activities now underway. Links provided on each gene page direct readers to MSeqDR for new findings, up-to-date genomic variant data, and user friendly informatics tools accessible to general clinicians and sophisticated geneticists or bioinformaticians alike, ensuring access to updated information on each condition. - Provides a readily intelligible, all-in-one reference of known mitochondrial disease genes and their associated conditions - Features live links to Mitochondrial Disease Sequence Data Resource (MSeqDR) pages with regularly updated genetic variant data and bioinformatics tools - Covers the inheritance patterns, age spectrum affected, major clinical features, therapeutics, support groups, and research currently under way for over 250 mitochondrial diseases＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	17,447円
Mitochondrial DNA and the Immuno-inflammatory Response: New Frontiers to Control Specific Microbial Diseases Volume: 3【電子書籍】[ Dilvani Oliveira Santos ] 楽天Kobo電子書籍ストア	＜p＞Mitochondria are multifunctional organelles that actively participate in the immune-inflammatory response in various pathologies. This volume updates readers on knowledge about mitochondria function. The editors have compiled six chapters about inflammation in its broadest sense, with contributions from active groups of cell biologists, infectologists and pathologists.The chapters in this volume focus on research related to five notable diseases:(1) two diseases (one bacterial and one viral) in which the exacerbation of the inflammatory response can lead to neuropathies: leprosy (one of the oldest diseases in the world) and Zika fever (a disease relatively new in Brazil)(2) three diseases (two bacterial and one viral) in which the exacerbation of the inflammatory response can lead to irreversible lung damage that can cause rapid death: tuberculosis, pneumonia and the most recent global disease, COVID- 19.New information about mitochondrial biology is presented, such as the effect of aerobic physical exercise as a stimulator for mitochondria multiplication, and the role of mitochondrial damage in inducing immune-inflammatory responses to pathogens. The contents shed light on mitochondrial biochemical pathways that could serve as potential therapeutic targets.This is an important reference for scholars (cell biologists, microbiologists) in universities, hospitals and scientific research centers working on biological and biomedical problems, and for health professionals involved in infection control.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	4,704円
Mitochondrial DNA Methods and Protocols【電子書籍】楽天Kobo電子書籍ストア	＜p＞This volume compiles a comprehensive range of methods to study key aspects of mitochondrial DNA including nucleoid structure and packaging, replication, genome integrity, and disease. Chapters are organized into eight methodological sections that cover ＜em＞in vitro＜/em＞ and ＜em＞in vivo＜/em＞ methods, including for mtDNA isolation, visualization, deep sequencing, gene editing, and diagnostic aspects of mtDNA disease. Written in the format of the highly successful ＜em＞Methods in Molecular Biology＜/em＞ series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.＜/p＞＜p＞Authoritative and cutting-edge, ＜em＞Mitochondrial DNA: Methods and Protocols＜/em＞ aims to be useful and informative for researchers and clinicians with an interest in mitochondrial DNA.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	26,740円
Cellular and Molecular Basis of Mitochondrial Inheritance Mitochondrial Disease and Fitness【電子書籍】楽天Kobo電子書籍ストア	＜p＞This new volume of our successful book series ＜em＞Advances in Anatomy, Embryology and Cell Biology＜/em＞ is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including ＜em＞Drosophila,＜/em＞＜em＞C. elegans,＜/em＞ bivalve molusc ＜em＞Mytilus＜/em＞ and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	13,369円
Mitochondrial Function, Part B Mitochondrial Protein Kinases, Protein Phosphatases and Mitochondrial Diseases【電子書籍】[ William S. Allison ] 楽天Kobo電子書籍ストア	＜p＞In this second of two new volumes covering mitochondria, methods developed to assess the number and function of nuclear-encoded proteins in the mitochondrion are presented. Chapters focus on the regulation of mitochondrial function and mitochondrial diseases, with a section emphasizing the mitochondrial defects associated with type 2 diabetes. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. With more than 450 volumes published, each volume presents material that is relevant in today's labs, truly an essential publication for researchers in all fields of life sciences. - New methods focusing on the examination of normal and abnormal mitochondrial function are presented in an easy-to-follow format by the researchers who developed them - Along with a companion volume covering topics including mitochondrial electron transport chain complexes and reactive oxygen species, provides a comprehensive overview of modern techniques in the study of mitochondrial malfunction - Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	20,407円
Mitochondrial Dynamics and Neurodegeneration【電子書籍】楽天Kobo電子書籍ストア	＜p＞Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	18,231円
Earn Your Own PhD: Remember, Regulate & Restore ? A 6-Month Guide to Nervous System Healing, Gut Balance & Mitochondrial Repair【電子書籍】[ J.Dette Avalon ] 楽天Kobo電子書籍ストア	＜p＞Are you tired of chasing protocols, supplements, and quick fixes that never last?＜/p＞＜p＞Earn Your Own PhD: Remember, Regulate & Restore is not another detox or 21-day challenge. It is a six-month, step-by-step workbook designed to help you rebuild health from the inside outーby listening to your body's own intelligence.＜/p＞＜p＞Guided by J. Dette Avalon, ANP, this transformative program blends functional medicine, trauma-informed nervous system care, and holistic healing practices. Each month focuses on a powerful pillar of wellnessーmitochondrial repair, gut health, insulin resistance, metabolic flexibility, sleep optimization, hormonal balance, detoxification, and longevity.＜/p＞＜p＞You will learn how to regulate your nervous system, restore gut balance, and reclaim your energy without overwhelm. Simple practices, reflective journaling, and actionable tools make this a guide you can truly live, not just read.Health is not about doing moreーit is about remembering how to do less with more intention.＜/p＞＜p＞This is your Personal Health Directive. Your own PhD.Return to yourself. Rebuild trust. Restore your vitality.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	1,600円
Mathematical Modeling of Mitochondrial Swelling【電子書籍】[ Messoud Efendiev ] 楽天Kobo電子書籍ストア	＜p＞The mathematical models considered in this book can help to understand the swelling of mitochondria. For the first time, it presents new mathematical models of mitochondrial swelling that take into account, in particular, spatial effects. The results presented here could make it possible to predict properties of the underlying biological mechanisms. Taking into account that mitochondria could move within a cell, lead to a PDE-PDE model. The book discusses the well-posedness and long-term dynamics of solutions, depending on boundary conditions reflecting the in vitro and in vivo cases. These analytical and numerical results have inspired colleagues from the Institute of Pharmacology and Toxicology of the Helmholtz Center Munich to design new experiments justifying the theoretical and numerical results that are obtained. The book is intended for graduates students and researchers with a solid mathematical background and an interest in cell biology.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	6,076円
Mitochondrial Dysfunction in Biological Aging and Cancer Bio Hacks for Healthy Ageing and Longevity with Supplement: COQ10, Nitric-Oxide, L-Glutathione, Nmn, Taurine, Melatonin, Niacin, Methyl - Cobalamin, Urolithin-A, Glynac, Niacin, Na【電子書籍】楽天Kobo電子書籍ストア	＜p＞This book is about Mitochondrial dysfunction and how it impacts the cellular aging of different cells, tissues, and organs.＜br /＞ This book caters to everyone, helping them understand the basic factors that age you faster and how to combat this. However, it can also be used as a ready reckoner by nutritionists, medical students, biochemists, biotechnologists, fitness freaks, future physicians, and health enthusiasts.＜br /＞ The author has backed all the articles on supplements, vitamins, or certain molecules from the online resources available on PubMed, the National Library of MedicineーNational Institutes of Health, and other online resources mentioned in all the articles of every chapter.＜br /＞ Mitochondrial diseases/dysfunction are a group of metabolic disorders (Obesity, Type 2 Diabetes (T2DM), Fatty Liver and Inflammatory Bowel Diseases, Alzheimer's disease, Parkinson's disease etc.).＜br /＞ Mitochondrial dysfunction can be caused by various factors such as Inflammation, Oxidative Stress, Insulin Resistance, Multiple sclerosis, Muscular Dystrophy and Cancer which can lead to the following diseases: KIDNEY FAILURE, LIVER FAILURE, HEART ATTACK, PCOS, CANCER, DIABETES, OBESITY, PROSTATE ENLARGEMENT, FITS, INFERTILITY, ULCERATIVE COLITIS, LUNGS FAILURE, BLINDNESS, ERECTILE DYSFUNCTION, HORMONAL IMBALANCE, OVARIAN CYST, UTERUS FIBROIDS, AUTOIMMUNE DISEASE, INSOMNIA.＜br /＞ The author has done his research by going through online medical resources of bio hacks to prevent cancer and delay cellular aging by following supplements: CoQ10, Nitric-Oxide, L-glutathione, NMN, Taurine, Melatonin, NIACIN, Methyl-Cobalamin, Urolithin-A, GlyNAC, NIACIN, NAD+, SIRT6, Amino Acid, Omega Fatty 3 Acids, Vitamin D3 and Magnesium etc.＜br /＞ The author strongly recommends that you consult your physician before beginning any exercise program. The author is not a licensed healthcare provider, and he has no expertise in diagnosing, examining, or treating medical conditions of any kind or determining the effect of any specific Supplements/Vitamins on a medical condition.＜br /＞ The information presented in this book is strictly for educational purposes. The author urges you Not to engage in self-diagnosis or treatment based solely on the knowledge acquired from this book. You must consult a medical practitioner for any health concerns, as this book does not claim to provide any medical solutions for any health issues.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	430円
Reproduction Reborn How Science, Ethics, and Law Shape Mitochondrial Replacement Therapies【電子書籍】楽天Kobo電子書籍ストア	＜p＞＜strong＞A cutting-edge analysis of the global issues surrounding modern reproductive technologies＜/strong＞ Advances in assisted reproductive technologies have sparked global policy debates since the birth of the first so-called "test tube baby" in 1978. Today, mitochondrial replacement therapies represent the most recent advancement in assisted reproductive technologies, allowing some women with mitochondrial diseases to birth babies without those diseases. In the past decade, mitochondrial replacement therapies have captured public sentiment, reigniting debates around social views of reproductive rights and the appropriate legal and political response. ＜em＞Reproduction Reborn＜/em＞ guides readers through the history and science of mitochondrial replacement therapies and the various attempts to control them. Leading experts from medicine, genetics, ethics, law, and policy explore the influence of public debate on the evolving shape of these technologies and their subsequent regulation. They highlight case studies from both developed and developing countries across the globe, including recent legislation in Australia and China. They further identify the ethical, legal, and societal norms that need to be addressed by policymakers and communities as more and more people seek to gain access to these treatments. Given the importance of reproduction in family life and cultural identity, clinicians and policymakers must understand how regulatory regimes around mitochondrial replacement therapies have evolved to illuminate the processes and challenges of governing reproduction in a fast-moving world. Informative and global in scope, ＜em＞Reproduction Reborn＜/em＞ explores how advancements in assisted reproductive technologies challenge core values surrounding the rights and responsibilities of modern-day family units.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	6,060円
Mitochondrial Case Studies Underlying Mechanisms and Diagnosis【電子書籍】楽天Kobo電子書籍ストア	＜p＞Mitochondrial Case Studies: Underlying Mechanisms and Diagnosis offers the science behind mitochondrial disease with a case studies approach. Since mitochondrial diseases are diverse and influenced by genetic, environmental, and social-economic factors, this publication will help students, physicians, scientists, health care students, and families recognize and accurately diagnose mitochondrial disease and learn about potential treatments. - Reviews case studies as a helpful teaching tool to increase awareness and improve diagnosis - Provides information on underlying mechanisms of mitochondrial disease - Includes basic mitochondrial dysfunction research through patient case studies to best illustrate the entire disease process＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	10,569円