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12件中 1件 - 12件
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| 商品 | 説明 | 価格 |
|---|---|---|
 Mitochondrial Diseases【電子書籍】[ Wiley ] 楽天Kobo電子書籍ストア | ＜p＞This collection of reviews and protocols provides the reader with an introduction to the current state of knowledge on how various diseases are related to mitochondrial dysfunction. Mitochondria contain their own genome, a small, circular double-stranded DNA (mtDNA), and alterations in mtDNA may play an important role in the multistep carcinogenesis of at least some types of human cancer. In addition to mutations of mtDNA, many mitochondrial syndromes are due to abnormalities in nuclear genes related to oxidative phosphorylation (OXPHOS). Mitochondrial tRNA (＜em＞MTT＜/em＞) gene mutations are an important cause of human morbidity and are associated with a wide range of pathology, from isolated organ?]specific diseases such as myopathy or hearing loss, to multisystem disorders with encephalopathy, gastrointestinal dysmotility, and life?]threatening cardiomyopathy. The relationship of the mitochondrion organelle to aging and longevity is also discussed.＜/p＞ ＜p＞Laboratory protocols describe methodology to characterize mtDNA heteroplasmy by parallel sequencing. Each eukaryotic cell contains hundreds of mitochondria with hundreds of mitochondria genomes. Mutant and wild-type mtDNA may co-exist as heteroplasmy, and cause human disease. The purpose of this protocol is to simultaneously determine mtDNA sequence and quantify the heteroplasmic level. Another protocol describes procedures for obtaining tissue sections and cell material suitable for histological evaluation of OXPHOS activity and integrity and immunodetection of the complexes in tissue from patients suspected of mitochondrial disease. Emphasis lies on the diagnostic potential of these techniques to differentiate mtDNA from nuclear mutations.＜/p＞ ＜p＞This e-book ー a curated collection from eLS, WIREs, and Current Protocols ー offers a fantastic introduction to the field of mitochondrial diseases for students or interdisciplinary collaborators.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 4,559円 |
 【中古】【輸入品・未使用】Understanding Mitochondrial Diseases ムジカ＆フェリーチェ楽天市場店 | 【中古】【輸入品・未使用】Understanding Mitochondrial Diseases【メーカー名】Foster Academics【メーカー型番】【ブランド名】Foster Academics【商品説明】Understanding Mitochondrial Diseases当店では初期不良に限り、商品到着から7日間は返品を 受付けております。こちらは海外販売用に買取り致しました未使用品です。買取り致しました為、中古扱いとしております。他モールとの併売品の為、完売の際はご連絡致しますのでご了承下さい。速やかにご返金させて頂きます。ご注文からお届けまで1、ご注文⇒ご注文は24時間受け付けております。2、注文確認⇒ご注文後、当店から注文確認メールを送信します。3、配送⇒当店海外倉庫から取り寄せの場合は10〜30日程度でのお届けとなります。国内到着後、発送の際に通知にてご連絡致します。国内倉庫からの場合は3〜7日でのお届けとなります。 ※離島、北海道、九州、沖縄は遅れる場合がございます。予めご了承下さい。お電話でのお問合せは少人数で運営の為受け付けておりませんので、メールにてお問合せお願い致します。営業時間 月〜金 10:00〜17:00お客様都合によるご注文後のキャンセル・返品はお受けしておりませんのでご了承下さい。 | 59,437円 |
 Mitochondria in Obesity and Type 2 Diabetes Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. - Synthesizes actual knowledge on mitochondrial function - Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes - Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression - Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 15,861円 |
 Mitochondrial Diseases Theory, Diagnosis and Therapy【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Mitochondrial diseases comprise a clinically and genetically heterogeneous group of rare disorders that may affect virtually any system of the body at any age. Due to their complexity, understanding and diagnosing these diseases requires a multidisciplinary approach.＜/p＞ ＜p＞This book provides an update on the major features of human mitochondrial diseases: genetic bases, pathophysiology, diagnosis, and treatment, and of the new technologies involved in the diagnosis and on the characterization of patients. The 11 chapters examine the unique complex interactions between the mitochondrial and the nuclear genomes involved in the biogenesis and the regulation of the mitochondrial respiratory chain, and their relevance to human disease. We discuss the traditional biochemical and genetic approaches, as well as the new omic technologies, and the cellular and animal models used in mitochondrial research. The last chapter is dedicated to the current treatment options.＜/p＞ ＜p＞Authors are worldwide experts in these fields and integrate expertise in both basic science and clinical research.＜/p＞ ＜p＞This book is particularly important for both scientists and clinicians interested in the diagnosis and treatment of these diseases.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 17,016円 |
 Mitochondrial Diseases【電子書籍】[ Rita Horvath ] 楽天Kobo電子書籍ストア | ＜p＞Mitochondrial Diseases, Volume 194 presents the most common clinical manifestations, providing an up-to-date summaries on the clinical presentations, diagnostic processes, genetic counseling and treatment options in mitochondrial diseases. Contents include specialist biochemical analyses and targeted molecular genetic testing, as well as first-line genome-wide sequencing to accelerate speed of diagnosis while avoiding time-consuming, expensive and invasive investigations. Establishing a genetic diagnosis allows patients with mitochondrial diseases to have reproductive options, all of which are covered within.This book is intended for neurologists to help them recognize and manage patients with mitochondrial diseases. - Examines the pathophysiology of mitochondrial diseases and disorders - Focuses on neurological symptoms of mitochondrial diseases - Presents myopathies, neuropathies, epilepsy, ataxia, paraplegias, and more - Covers histology, metabolism, genetic, and neuroimaging diagnostics - Summarizes both available and emerging therapies - Includes clinical trials, the use of biomarkers and reproductive options＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 29,077円 |
 Mitochondrial DNA and the Immuno-inflammatory Response: New Frontiers to Control Specific Microbial Diseases Volume: 3【電子書籍】[ Dilvani Oliveira Santos ] 楽天Kobo電子書籍ストア | ＜p＞Mitochondria are multifunctional organelles that actively participate in the immune-inflammatory response in various pathologies. This volume updates readers on knowledge about mitochondria function. The editors have compiled six chapters about inflammation in its broadest sense, with contributions from active groups of cell biologists, infectologists and pathologists.The chapters in this volume focus on research related to five notable diseases:(1) two diseases (one bacterial and one viral) in which the exacerbation of the inflammatory response can lead to neuropathies: leprosy (one of the oldest diseases in the world) and Zika fever (a disease relatively new in Brazil)(2) three diseases (two bacterial and one viral) in which the exacerbation of the inflammatory response can lead to irreversible lung damage that can cause rapid death: tuberculosis, pneumonia and the most recent global disease, COVID- 19.New information about mitochondrial biology is presented, such as the effect of aerobic physical exercise as a stimulator for mitochondria multiplication, and the role of mitochondrial damage in inducing immune-inflammatory responses to pathogens. The contents shed light on mitochondrial biochemical pathways that could serve as potential therapeutic targets.This is an important reference for scholars (cell biologists, microbiologists) in universities, hospitals and scientific research centers working on biological and biomedical problems, and for health professionals involved in infection control.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 4,574円 |
 Mitochondrial DNA and Diseases【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinicalstudents and researchers in the field of mtDNA?associated diseases.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,231円 |
 Mitochondrial Function, Part B Mitochondrial Protein Kinases, Protein Phosphatases and Mitochondrial Diseases【電子書籍】[ William S. Allison ] 楽天Kobo電子書籍ストア | ＜p＞In this second of two new volumes covering mitochondria, methods developed to assess the number and function of nuclear-encoded proteins in the mitochondrion are presented. Chapters focus on the regulation of mitochondrial function and mitochondrial diseases, with a section emphasizing the mitochondrial defects associated with type 2 diabetes. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. With more than 450 volumes published, each volume presents material that is relevant in today's labs, truly an essential publication for researchers in all fields of life sciences. - New methods focusing on the examination of normal and abnormal mitochondrial function are presented in an easy-to-follow format by the researchers who developed them - Along with a companion volume covering topics including mitochondrial electron transport chain complexes and reactive oxygen species, provides a comprehensive overview of modern techniques in the study of mitochondrial malfunction - Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 20,407円 |
 Mitochondrial Dysfunction and Nanotherapeutics Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine【電子書籍】 楽天Kobo電子書籍ストア | ＜p＞Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies. - Contains detailed information on mitochondrial dysfunction - Reviews our current understanding of the role of mitochondria in aging - Includes coverage of specific conditions, including sports and affective disorders, among others - Discusses mitochondria targeted delivery of therapeutic compounds＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,504円 |
 Mitochondrial DNA and the Immuno-inflammatory Response: New Frontiers to Control Specific Microbial Diseases【電子書籍】[ Dilvani Oliveira Santos ] 楽天Kobo電子書籍ストア | ＜p＞Mitochondria are multifunctional organelles that actively participatein the immune-inflammatory response in various pathologies. This volume updates readers onknowledge about mitochondria function. The editors have compiled six chaptersabout inflammation in its broadest sense, with contributions from active groupsof cell biologists, infectologists and pathologists. The chapters in this volume focus on research related to five notablediseases:(1) two diseases (one bacterial and one viral) in which theexacerbation of the inflammatory response can lead to neuropathies: leprosy(one of the oldest diseases in the world) and Zika fever (a disease relativelynew in Brazil) (2) three diseases (two bacterial and one viral) in which theexacerbation of the inflammatory response can lead to irreversible lung damagethat can cause rapid death: tuberculosis, pneumonia and the most recent globaldisease, COVID- 19. New information about mitochondrial biology is presented, such as theeffect of aerobic physical exercise as a stimulator for mitochondriamultiplication, and the role of mitochondrial damage in inducing immune-inflammatoryresponses to pathogens. The contents shed light on mitochondrial biochemicalpathways that could serve as potential therapeutic targets. This is an important reference for scholars (cell biologists,microbiologists) in universities, hospitals and scientific research centersworking on biological and biomedical problems, and for health professionalsinvolved in infection control.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 5,717円 |
 Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases【電子書籍】[ Takuya Hidaka ] 楽天Kobo電子書籍ストア | ＜p＞This book describes the author’s work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole?imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced in live cells. Furthermore, because nuclear DNA is another important target for treating mitochondrial diseases, the author demonstrated that tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity in cells.＜/p＞ ＜p＞This work willattract readers’ interest because it paves the way for a transgene-free chemical gene therapy for mitochondrial diseases. The book includes a detailed description of experimental procedures, especially compound synthesis. This description helps readers to have a clear image of the author’s studies and to perform similar and extended studies themselves.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 18,231円 |
 Current Progress of Mitochondrial Transplantation: A new paradigm of therapeutic intervention promoting Neuronal Re-generation for Neurodegenerative Diseases, Stroke, & CNS injury. An Overview【電子書籍】[ hakimuddin saboowala ] 楽天Kobo電子書籍ストア | ＜p＞Neuronal Re-generation for Neurodegenerative Diseases, Stroke, & CNS injury. An Overview.＜/p＞ ＜p＞Mitochondria are the major source of intracellular adenosine triphosphate (ATP) and play an essential role in a plethora of physiological functions, including the regulation of metabolism and the maintenance of cellular homeostasis.＜/p＞ ＜p＞Mutations of mitochondrial DNA, proteins and impaired mitochondrial function have been implicated in the neurodegenerative diseases, stroke and injury of the central nervous system (CNS).＜/p＞ ＜p＞The dynamic feature of mitochondrial fusion, fission, trafficking and turnover have also been documented in these diseases.＜/p＞ ＜p＞A major bottleneck of traditional approach to correct mitochondria-related disorders is the difficulty of drugs or gene targeting agents to arrive at specific sub-compartments of mitochondria.＜/p＞ ＜p＞Moreover, the diverse nature of mitochondrial mutations among patients makes it impossible to develop one drug for one disease.＜/p＞ ＜p＞To this end, mitochondrial transplantation presents a new paradigm of therapeutic intervention that benefits neuronal survival and regeneration for;＜/p＞ ＜p＞Neurodegenerative diseases,＜br /＞ Stroke, and＜br /＞ CNS injury.＜/p＞ ＜p＞Supplement of healthy mitochondria to damaged neurons has been reported to promote neuronal viability, activity and neurite re-growth.＜/p＞ ＜p＞Thus an attempt has been made in this Booklet to provide an overview of the recent advance and development on emerging mitochondrial therapy.＜/p＞ ＜p＞…Dr. H. K. Saboowala.＜/p＞ ＜p＞M.B.(Bom) .M.R.S.H.(London)＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 | 806円 |