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Drug Disposition and Pharmacokinetics From Principles to Applications【電子書籍】[ Stephen H. Curry ] 楽天Kobo電子書籍ストア	＜p＞This is an authoritative, comprehensive book on the fate of drug molecules in the body, including implications for pharmacological and clinical effects. The text provides a unique, balanced approach, examining the specific physical and biological factors affecting the absorption, distribution, metabolism and excretion of drugs, together with mathematical assessment of the concentrations in plasma and body fluids. Understanding the equations requires little more than a basic knowledge of algebra, laws of indices and logarithms, and very simple calculus. A companion web site contains additional illustrations, further equations and numerous worked examples.＜/p＞＜p＞Whilst this book has its roots in the highly acclaimed book of the same name, written by Stephen Curry nearly thirty years ago, it is essentially a new book having been restructured and largely rewritten. This readable and informative book is an invaluable resource for professionals and students needing to develop a rational approach to the investigation and application of drugs.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	12,113円
Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications【電子書籍】[ Hartmut Derendorf ] 楽天Kobo電子書籍ストア	＜p＞Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	17,908円
Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents【電子書籍】楽天Kobo電子書籍ストア	＜p＞This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinicians, students, researchers, and members of the pharmaceutical industry alike.＜/p＞＜p＞The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories andwith reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together,or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result.＜/p＞＜p＞The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology.Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions,isfrequently updated. However, with information presented on a host of different platforms, and in differentformats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	14,585円
Computational Pharmacokinetics【電子書籍】[ Anders Kallen ] 楽天Kobo電子書籍ストア	＜p＞Being that pharmacokinetics (PK) is the study of how the body handles various substances, it is not surprising that PK plays an important role in the early development of new drugs. However, the clinical research community widely believes that mathematics in some way blurs the true meaning of PK. Demonstrating that quite the opposite is true, Computational Pharmacokinetics outlines the fundamental concepts and models of PK from a mathematical perspective based on clinically relevant parameters.＜/p＞＜p＞After an introductory chapter, the book presents a noncompartmental approach to PK and discusses the numerical analysis of PK data, including a description of an absorption process through numerical deconvolution. The author then builds a simple physiological model to better understand PK volumes and compares this model to other methods. The book also introduces compartmental models, discusses their limitations, and creates a general-purpose type of model. The final chapter looks at the relationship between drug concentration and effect, known as PK/pharmacodynamics (PD) modeling.＜/p＞＜p＞With both a solid discussion of theory and the use of practical examples, this book will enable readers to thoroughly grasp the computational factors of PK modeling.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	13,838円
Pharmacokinetics in Everyday Clinical Practice【電子書籍】[ Federico Pea ] 楽天Kobo電子書籍ストア	＜p＞This book provides a practical introduction to the main concepts of pharmacokinetics and how they can be applied in clinical settings, without using complicated mathematical equations. Essential information on approaches to drug-dosing and monitoring in special populations, including patients with renal and hepatic diseases and elderly patients, are given. Charts, illustrations and examples of calculations are added to clarify concepts and terminology of pharmacokinetics. It’s a guide for students and clinicians who want clear, useful guidance to the basic principles of pharmacokinetics and their application into clinical practice.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	1,774円
The ADME Encyclopedia A Comprehensive Guide on Biopharmacy and Pharmacokinetics【電子書籍】楽天Kobo電子書籍ストア	＜p＞＜em＞The ADME Encyclopedia＜/em＞ covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry).＜/p＞＜p＞Structured as alphabetically ordered entries with cross-references, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, gene delivery, pharmacometrics, pharmacokinetic drug interactions or in silicoand in vitro assessment of ADME properties＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	115,471円
Advances in Pharmacokinetics and Pharmacodynamics【電子書籍】楽天Kobo電子書籍ストア	＜p＞This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	13,369円
Pharmacokinetics: A Tutorial Study Guide Science Textbook Series【電子書籍】[ Nicoladie Tam ] 楽天Kobo電子書籍ストア	＜p＞"Pharmacokinetics" is a book chapter of the college-level textbook for the book volume in the Principles of Neuropsychopharmacology course. It is a part of the Science Textbook Series authored by Nicoladie Tam, Ph.D. that also includes the Principles of Biology course.＜/p＞＜p＞This book is written with specific pedagogical considerations to facilitate students' learning. It applies the proven best practices to motivate students in learning. It uses multiple pedagogical methodologies to engage students in active learning by participating in the knowledge acquisition process. It stimulates the curiosity of students by asking them questions and answering them immediately. It guides the students in their comprehension of knowledge by using examples and by giving them detailed explanations following the answers.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	350円
Biopharmaceutics and Pharmacokinetics Considerations【電子書籍】[ Rakesh Kumar Tekade ] 楽天Kobo電子書籍ストア	＜p＞Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce. - Examines the most recent developments in biopharmaceutics and pharmacokinetics for pharmaceutical sciences - Covers the principles, methodologies and technologies of biopharmaceutics and pharmacokinetics - Focuses on the pharmaceutical sciences, but also encompasses aspects of toxicology, neuroscience, environmental sciences and nanotechnology＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	21,147円
Biopharmaceutics and Clinical Pharmacokinetics An Introduction, Fourth Edition,【電子書籍】[ Robert E. Notari ] 楽天Kobo電子書籍ストア	＜p＞For a decade and a half, Biopharmaceutics and Clinical Pharmacokinetics has been used in theclassrooms around the world as an introductory textbook on biophannaceutics and phannacokinetics. Now, the new Fourth Edition, Revised and Expanded further enhances the preceding editions'proven features, introducing significant advances in clinical pharmacokinetics, pharmacokineticdesign of drugs and dosage forms, and model-independent analyses. Still usable without prior knowledge of calculus or kinetics, this successfully implemented workbookmaintains a carefully graduated "building block" presentation, incorporating sample problemsand exercises throughout for a thorough understanding of the material.Biopharmaceutics and Clinical Pharmacokinetics features a growth-oriented format that systematicallydevelops and interrelates all subject matter .. . introduces basic theory and fields of application... emphasizes model-independent pharmacokinetic analyses ... presents biopharmaceutical aspectsof product design and evaluation .. . offers a unique approach to teaching dosage regimen design andindividualization . .. and considers structural modification of drug molecules for problems associatedwith pharmacokinetics. As a comprehensive coverage of the basic principles and the recent achievements in the field, noother textbook does as much for students of pharmacy, pharmacology, medicinal chemistry, andmedicine, or for scientists who desire a simple but thorough introduction to theory and application.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	19,538円
Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery A Practical Guide for Pharmaceutical Scientists【電子書籍】[ Emile P. Chen ] 楽天Kobo電子書籍ストア	＜p＞＜strong＞Develop drugs with a greater understanding of their physiological effects＜/strong＞＜/p＞＜p＞Pharmaceutical scientists in the fields of pharmacokinetics and pharmacodynamics study how drugs behave in the body and how they reach their site of action to exert their intended pharmacological activities. Drug discovery stands to benefit enormously from the timely application of pharmacokinetics and pharmacodynamics in order to make informed decisions and solve practical problems.＜/p＞＜p＞＜em＞Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery＜/em＞ bridges between scientific concepts and practical industrial practice by bringing these principles to bear on every stage of the drug discovery process. Beginning with target identification and moving through each subsequent decision point including high throughput screening, hit-to-lead, lead optimization and candidate selection. The book offers a comprehensive guide to using various analytical tools including modeling and AI/ML for minimizing attrition, reducing costs, and more. The result is an invaluable tool in developing smarter and more effective drug discovery processes.＜/p＞＜p＞＜em＞Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery＜/em＞ readers will also find:＜/p＞＜ul＞＜li＞A work designed to make scientific principles accessible to pharmaceutical scientists in diverse areas, not just pharmacokinetists or DMPK scientists＜/li＞＜li＞Industrial examples, both positive and negative, showing pharmacokinetic and pharmacodynamic principles at work＜/li＞＜li＞Exercises throughout the book to encourage holistic and integrated thinking＜/li＞＜/ul＞＜p＞＜em＞Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery＜/em＞ is ideal for any researchers or professionals involved in drug discovery and development, including medicinal chemists, biopharmaceutics scientists, clinicians, project leaders, and many others.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	20,232円
Pharmacokinetics: Basics to Applications【電子書籍】[ Biswajit Mukherjee ] 楽天Kobo電子書籍ストア	＜p＞This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	9,723円
Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems【電子書籍】楽天Kobo電子書籍ストア	＜p＞A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles.＜/p＞＜p＞This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	34,033円
Handbook of Comparative Pharmacokinetics and Residues of Veterinary Therapeutic Drugs【電子書籍】[ Arthur L. Craigmill ] 楽天Kobo電子書籍ストア	＜p＞Handbook of Comparative Pharmacokinetics and Residues of Veterinary Therapeutic Drugs is a unique compilation of comparative pharmacokinetic data for veterinary therapeutic drugs. The book features an excellent introductory chapter on basic veterinary pharmacokinetics and includes pharmacological data taken from hundreds of primary research references. These data are presented in standardized units and are arranged in conveniently organized tables so that comparisons between data can be made easily. Much of the data is new and was taken from articles in which data was not subjected to pharmacokinetic analysis.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	47,216円
Drug Delivery Approaches Perspectives from Pharmacokinetics and Pharmacodynamics【電子書籍】[ Bret Berner ] 楽天Kobo電子書籍ストア	＜p＞＜strong＞Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field＜/strong＞＜/p＞＜p＞＜em＞Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics＜/em＞ delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes.＜/p＞＜p＞The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine.＜/p＞＜p＞Readers will also benefit from the inclusion of:＜/p＞＜ul＞＜li＞A thorough introduction to the utility of mathematical models in drug development and delivery＜/li＞＜li＞An exploration of the techniques and applications of physiologically based models to drug delivery＜/li＞＜li＞Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery＜/li＞＜li＞A review of integrated transdermal delivery and pharmacokinetics in development＜/li＞＜li＞An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms＜/li＞＜li＞Alternative endpoints to pharmacokinetics for topical delivery＜/li＞＜/ul＞＜p＞Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, ＜em＞Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics＜/em＞ will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	27,324円
Casebook in Clinical Pharmacokinetics and Drug Dosing【電子書籍】[ Henry Cohen ] 楽天Kobo電子書籍ストア	＜h4＞A STEP-BY-STEP APPROACH TO DESIGNING ACCURATE DOSING REGIMENS＜/h4＞＜p＞＜em＞Casebook in Pharmacokinetics and Drug Dosing＜/em＞ uses real-life cases to teach pharmacy students, pharmacists, and clinical pharmacists how to apply pharmacokinetics to formulate proper dosing regimens. In order to be as clinically relevant as possible, the book not only discusses drugs with readily available therapeutic serum levels, but places equal emphasis on high-alert agents with narrow therapeutic indexes.＜/p＞＜p＞Each drug chapter is written by clinical pharmacists who have hands-on experience in drug dosing and includes an overview of the drug’s pharmacology, including:＜/p＞＜ul＞＜li＞Indications＜/li＞＜li＞Mec hanisms of action＜/li＞＜li＞Toxicities＜/li＞＜li＞Pharmacokinetics＜/li＞＜/ul＞＜p＞There is comprehensive review and discussion of each drug's bioavailability, volume of distribution, clearance, half-life, therapeutic drug level monitoring, drug interactions, dosing, and availability. Each chapter is enhanced by numerous patient cases with clear step-by-step answers and explanations. Calculations, equations, and dosing recommendations are provided for each case.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	7,473円
200 MCQs in Clinical Pharmacokinetics【電子書籍】[ Hamza Alhamad ] 楽天Kobo電子書籍ストア	＜p＞This book contains 200 comprehensive multiple-choice questions in clinical pharmacokinetics, aiding pharmacy students and healthcare professionals in assessing their understanding of key concepts and principles in the field.＜/p＞＜p＞Pharmacokinetics is the branch of pharmacology concerned with studying how the body interacts with the administered drugs for the entire duration of exposure, including absorption, distribution, metabolism, and elimination (ADME). Clinical pharmacokinetics is the science that describes the absorption, distribution, metabolism, and elimination of drugs in patients requiring drug therapy. Clinical pharmacokinetics is concerned with applying pharmacokinetic principles to the safe and effective therapeutic management of drugs in individual patients.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	1,550円
A Short Guide to Clinical Pharmacokinetics【電子書籍】楽天Kobo電子書籍ストア	＜p＞This book is a complete resource on pharmacokinetics, pharmacodynamics and pharmacogenomics in clinical practice. It consists of seven chapters that cover various aspects of pharmacokinetics and its clinical applications. The chapters are structured to provide clear objectives and keywords are bolded throughout the text to facilitate understanding. The topics covered include the significance of pharmacokinetics in clinical practice, factors affecting pharmacokinetic parameters, pharmacokinetic drug interactions, therapeutic drug monitoring, dosage adjustment in different population groups, the influence of hepatic diseases on pharmacokinetics and the impact of pharmacogenomics on pharmacokinetics and pharmacodynamics. The book is written in simple language to make the concepts accessible to all readers. This book is a comprehensive resource for students pursuing a doctoral degree in pharmacy, as well as academicians and researchers in clinical pharmacokinetics.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	20,662円
The Art and Science of Physiologically-Based Pharmacokinetics Modeling【電子書籍】楽天Kobo電子書籍ストア	＜p＞This state-of-the-art text describes the science behind the system and drug-dependent components of PBPK models, its applications in translational and regulatory science, e.g., guiding drug discovery and development, and supporting precision medicine initiatives. To incorporate state-of-the-art knowledge, each chapter is written by leaders in the field and illustrated by clear case studies. Connecting basic and applied science, this book explores the potential of PBPK modeling for improving therapeutics and is designed for a wide audience encompassing graduate students as well as biopharmaceutics scientists and clinical pharmacologists.＜/p＞＜p＞Features:＜/p＞＜ol＞＜li＞＜p＞Provides a basic understanding of the physiologically-based pharmacokinetic modeling and its applications＜/p＞＜/li＞＜li＞＜p＞Assists the reader in understanding product performance to allow for rapid product development and establish bioequivalence＜/p＞＜/li＞＜li＞＜p＞Well-constructed content and added value of real examples＜/p＞＜/li＞＜li＞＜p＞Illustrates how using available resources via modeling and simulation leads to a reduction in the costs related to drug development, which directly affects the costs to patients＜/p＞＜/li＞＜/ol＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	10,908円
Pharmacology & Pharmacokinetics A Basic Reader【電子書籍】楽天Kobo電子書籍ストア	＜p＞Effective drug administration is a crucial skill for any practitioner working in the critical care unit. This book, in providing a concise account of the fundamental principles of pharmacology and pharmacokinetics, equips the critical care physician for such a task. In addition to the principles of pharmacology and pharmacokinetics, this volume alerts the reader to factors that affect drug action such as disease, pregnancy and age, and advises on how to adjust drug dosages accordingly. The specialist therapeutics covered comprise drugs targeting the gastro-intestinal tract, sedation, non-opioid analgesia and opiates. A quick and easy reference, this volume will prove a valuable asset for both trainees and fully qualified practitioners in critical care.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	7,900円
Mass Spectrometry in Drug Metabolism and Pharmacokinetics【電子書籍】楽天Kobo電子書籍ストア	＜p＞This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	16,838円
New Horizons in Predictive Drug Metabolism and Pharmacokinetics【電子書籍】楽天Kobo電子書籍ストア	＜p＞Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk.＜br /＞ Discussions of critical properties that are determinants of a compound’s metabolic and pharmacokinetic fate follow introductory chapters. The Drug Discovery process increasingly incorporates pharmacokinetics and drug metabolism screening and focus has shifted towards in silico, computational and systems biology approaches. Core chapters reflect this and the recent interest and need to assess the role of transporters, along with drug metabolizing enzymes, as potential determinants of pharmacokinetic behaviour, toxicity and drug-drug interactions. Lastly, chapters cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and postulate future directions and opportunities.＜br /＞ Leading experts from academia, industry and regulatory bodies across the globe contribute their knowledge to this book, which scientists involved in many aspects of the drug discovery process, as well as regulators and postgraduate students, will find a useful resource.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	33,906円
Winter's Basic Clinical Pharmacokinetics【電子書籍】[ Beringer, Paul ] 楽天Kobo電子書籍ストア	＜p＞Popular among students and clinicians for its easy-to-read, case-study format, Winter’s Basic Clinical Pharmacokinetics, 7th Edition, clarifies complex concepts to help you confidently apply pharmacokinetics and therapeutic drug monitoring to patient care. This straightforward text is divided into two parts, reviewing basic pharmacokinetic principles in Part I and illustrating the clinical application of these principles to the most commonly encountered problems in Part II. The significantly updated and expanded 7th Edition adds essential coverage of the use of pharmacokinetics in managing obesity, pregnancy, as well as anticoagulation＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	11,950円
Pharmacokinetics and Metabolism in Drug Design【電子書籍】[ Raimund Mannhold ] 楽天Kobo電子書籍ストア	＜p＞In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts.＜/p＞＜p＞While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	19,351円
Drug Metabolism and Pharmacokinetics Frontiers, Strategies, and Applications【電子書籍】楽天Kobo電子書籍ストア	＜p＞＜strong＞Practical, state-of-the-art pharmacokinetic research methods, ideas, advancements, applications, and strategies＜/strong＞＜/p＞＜p＞Drawing on a wealth of extensive practical experience and theoretical research, ＜em＞Drug Metabolism and Pharmacokinetics＜/em＞ encapsulates the most recent advancements and illustrative applications in the field. Sixty-eight relatively independent yet interconnected articles are included, each offering a unique perspective and providing in-depth interpretation. Readers can either read systematically or select specific topics of interest from the table of contents.＜/p＞＜p＞Basic concepts, frontier advancements, DMPK research strategies, and technical methods are covered for novel drug modalities and therapeutics in different disease areas. The book encompasses a wide range of application and validation cases for DMPK research, including studies in ＜em＞in vitro＜/em＞ ADME, ＜em＞in vivo＜/em＞ pharmacokinetics, metabolite profiling and identification, radiolabeled ADME, and bioanalysis. Case studies showing the application of topics covered are included throughout, along with valuable insights into problem-solving and critical thinking.＜/p＞＜p＞Written by a team of scientists specializing in DMPK research from the DMPK Department of WuXi AppTec, ＜em＞Drug Metabolism and Pharmacokinetics＜/em＞ discusses sample topics including:＜/p＞＜ul＞＜li＞ADME properties, metabolite identification, and bioanalytical strategies for oligonucleotide drugs＜/li＞＜li＞Strategies and challenges in the determination of drug-to-antibody ratio (DAR) values of antibody-drug conjugates (ADCs)＜/li＞＜li＞Breaking barriers in CNS drug development with intrathecal and intracerebroventricular administration＜/li＞＜li＞Application and detection techniques of biomarkers in drug development＜/li＞＜li＞Flux dialysis method for assessing plasma protein binding of high protein-binding drugs＜/li＞＜/ul＞＜p＞＜em＞Drug Metabolism and Pharmacokinetics＜/em＞ is an essential forward-thinking reference on the subject for pharmacy students, pharmaceutical industry researchers, and DMPK scientists, especially those exploring novel drug modalities.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	33,092円
Acute Leukemias Pharmacokinetics and Management of Relapsed and Refractory Disease【電子書籍】楽天Kobo電子書籍ストア	画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	6,076円
Pharmacokinetics and Pharmacodynamics of Novel Drug Delivery Systems: From Basic Concepts to Applications A Machine-Generated Literature Overview【電子書籍】楽天Kobo電子書籍ストア	＜p＞The book delves into the intricate realm of pharmacokinetics and pharmacodynamics as they apply to modern advancements in drug delivery systems. It offers a comprehensive exploration of novel drug delivery methods, with a particular focus on nanoparticles and nanocarriers. The absorption, distribution, metabolism, and excretion processes of nanoparticles are extensively examined. It also covers various evaluation models, spanning from preclinical to clinical, aimed at assessing the effectiveness and safety of nanoparticles in drug delivery.＜/p＞＜p＞It also covers the integration of Artificial Intelligence and Machine Learning in pharmacokinetics and pharmacodynamics, showcasing how these cutting-edge approaches can enhance our understanding of drug behavior and optimize therapeutic outcomes. It serves as a comprehensive guide, highlighting the fusion of traditional pharmacological concepts with contemporary drug delivery systems and innovative technologies, all in the pursuit of refining medical treatments and patient care and is a valuable resource for academicians, researchers, and pharmacologists.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	19,447円
Pharmacokinetics for the Pharmaceutical Scientist【電子書籍】[ John G. Wagner ] 楽天Kobo電子書籍ストア	＜p＞Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	13,838円
Circadian Pharmacokinetics【電子書籍】楽天Kobo電子書籍ストア	＜p＞This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	17,016円
ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins Applications in Drug Discovery and Development【電子書籍】[ Honghui Zhou ] 楽天Kobo電子書籍ストア	＜p＞With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs.＜/p＞＜p＞? Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs＜br /＞ ? Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective＜br /＞ ? Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines＜br /＞ ? Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan＜br /＞ ? Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	18,888円