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407件中 151件 - 180件  1 2 3 4 5 6 7 8 9 10 11
商品説明価格

Targeting the Broadly Pathogenic Kynurenine Pathway【電子書籍】

楽天Kobo電子書籍ストア
<p>Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 18,231円

Molecular Diagnosis and Targeting for Gynecologic Malignancy【電子書籍】

楽天Kobo電子書籍ストア
<p>This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance.</p> <p>Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response.</p> <p><em>Molecular Diagnosis and Targeting for Gynecologic Malignancy</em> appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 6,076円

Salinity Responses and Tolerance in Plants, Volume 1 Targeting Sensory, Transport and Signaling Mechanisms【電子書籍】

楽天Kobo電子書籍ストア
<p>Soil salinity is a key abiotic-stress and poses serious threats to crop yields and quality of produce. Owing to the underlying complexity, conventional breeding programs have met with limited success. Even genetic engineering approaches, via transferring/overexpressing a single ‘direct action gene’ per event did not yield optimal results. Nevertheless, the biotechnological advents in last decade coupled with the availability of genomic sequences of major crops and model plants have opened new vistas for understanding salinity-responses and improving salinity tolerance in important glycophytic crops. Our goal is to summarize these findings for those who wish to understand and target the molecular mechanisms for producing salt-tolerant and high-yielding crops. Through this 2-volume book series, we critically assess the potential venues for imparting salt stress tolerance to major crops in the post-genomic era. Accordingly, perspectives on improving crop salinity tolerance by targeting the sensory, ion-transport and signaling mechanisms are presented here in volume 1. Volume 2 will focus on the potency of post-genomic era tools that include RNAi, genomic intervention, genome editing and systems biology approaches for producing salt tolerant crops.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 12,154円

A Kill is A Kill: Asymmetrically Attacking U.S. Airpower - Tactical and Operational Level, Targeting, On the Ramp, Aircraft Carriers, Deception, Urban Warfare, Israeli Experience, MANPADS, Lasers【電子書籍】[ Progressive Management ]

楽天Kobo電子書籍ストア
<p>This excellent report has been professionally converted for accurate flowing-text e-book format reproduction. Efforts towards organizing, training, and equipping U.S. airpower assets remain based on the assumption of face-to-face conventional confrontations. This is a comforting hypothesis, as U.S. technological superiority should keep the odds stacked in our favor for decades to come. Air strategists may be overlooking the fact, however, that this very technological superiority may force adversaries to counter U.S. airpower with other than conventional methods. Couple this with the strong possibility that the interests of the U.S. and our opponents will likely be found on opposite ends of the spectrum of war, and U.S. airpower could be in for some surprises. This study analyzes the asymmetric threat to U.S. airpower across the political, operational, and tactical levels of war and examines whether the U.S. has adequately prepared itself to counter asymmetrical measures against its airpower assets. The answers are not reassuring. U.S. airpower is not likely to overwhelming technological capability by increasing friction levels and changing our visions of surgical warfare into an attrition reality. They will attempt to inflict "virtual attrition" as well by changing U.S. targeting strategies and reducing our effectiveness while buying themselves time to attain their objectives. In this respect, U.S. airpower can be strategically defeated.</p> <p>Chapter 1: INTRODUCTION * The Question * Background and Significance of the Problem * Limitations of the Study * Methodology * Terminology * Preview of the Argument * Chapter 2: ASYMMETRIC RESPONSES AT THE POLITICAL LEVEL * Propaganda * Coalition Busting * Enemy Measures to Change U.S. Targeting Strategy * Conclusion * Chapter 3: ASYMMETRIC RESPONSES AT THE OPERATIONAL LEVEL * Attacking Airpower on the Ramp * Aircraft Carriers * Deception * Urban Warfare * Conclusion * Chapter 4: ASYMMETRIC RESPONSES AT THE TACTICAL LEVEL * The Israeli Experience * MANPADS * The Laser Threat * Conclusion * CONCLUSIONS</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 771円

Modifications and Targeting of Protein Termini Part A【電子書籍】[ Thomas Arnesen ]

楽天Kobo電子書籍ストア
<p><em>Modifications and Targeting of Protein Termini, Volume 684</em> in the <em>Methods in Enzymology</em> series serial highlights new advances in the field, with this new volume presenting interesting chapters pn a variety of timely topics, including Optimizing purification and activity assays of N-terminal methyltransferase complexes, In vitro reconstitution of hierarchical steps of Arg/N-degron pathway, Identification of N-degrons and N-recognins by using peptide-pull-downs combined with quantitative proteomics, A decoupled Virotrap approach to study the interactomes of N-terminal proteoforms, Monitoring ADO-dependent proteolysis in cells using fluorescent reporter proteins, Site-specific a-N-terminal methylation on peptides through chemical and enzymatic methods, and more.</p> <p>Additional sections cover Monitoring the interactions between N-degrons and N-recognins of the Arg/N-degron pathway, Characterization and chemical modulation of p62/SQSTM1 as an autophagic N-recognin of the Arg/N-degron pathway, Analysis of higher plant N-degron pathway components and substrates via expression in S. cerevisiae, and so much more.</p> <ul> <li>Provides the authority and expertise of leading contributors from an international board of authors</li> <li>Presents the latest release in the Methods in Enzymology serials</li> <li>Updated release includes the latest information on Modifications and Targeting of Protein Termini</li> </ul>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 23,145円

Therapeutic Targeting of RAS Mutant Cancers【電子書籍】[ Edward C. Stites ]

楽天Kobo電子書籍ストア
<p>The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 2,351円

Personalized Anaesthesia Targeting Physiological Systems for Optimal Effect【電子書籍】

楽天Kobo電子書籍ストア
<p>Personalized Anaesthesia presents a modern vision of anaesthesia. Integrating technology and knowledge from leading experts in the field, this book will change the way anaesthesia is both taught and practiced. Modern practice requires the anaesthetist to provide patient-specific management. This is the first resource to be organised by the desired physiological effect, rather than by drug groupings, explaining how physiological changes can be produced and controlled according to the characteristics of each patient and the particular surgical context. The book integrates physiology, pharmacology and technology, and applies these concepts in a systematic manner to each homeostatic system. This will optimise drug titration, effect quantification and decision making in anaesthesia practice to match the needs of the individual patient. Complex mathematical and scientific concepts are explained using accessible text, colour illustrations throughout and graphs. This is an essential text for any consultant or trainee working in anaesthesia.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 12,498円

PowerShell and Python Together Targeting Digital Investigations【電子書籍】[ Chet Hosmer ]

楽天Kobo電子書籍ストア
<p>Bring together the Python programming language and Microsoft’s PowerShell to address digital investigations and create state-of-the-art solutions for administrators, IT personnel, cyber response teams, and forensic investigators.</p> <p>You will learn how to join PowerShell's robust set of commands and access to the internals of both the MS Windows desktop and enterprise devices and Python's rich scripting environment allowing for the rapid development of new tools for investigation, automation, and deep analysis.</p> <p>***PowerShell and Python Together***takes a practical approach that provides an entry point and level playing field for a wide range of individuals, small companies, researchers, academics, students, and hobbyists to participate.</p> <p><strong>What You’ll Learn</strong></p> <ul> <li> <p>Leverage the internals of PowerShell for: digital investigation, incident response, and forensics</p> </li> <li> <p>Leverage Python to exploit already existing PowerShell CmdLets and aliases to build new automation and analysis capabilities</p> </li> <li> <p>Create combined PowerShell and Python applications that provide: rapid response capabilities to cybersecurity events, assistance in the precipitous collection of critical evidence (from the desktop and enterprise), and the ability to analyze, reason about, and respond to events and evidence collected across the enterprise</p> </li> </ul> <p><strong>Who This Book Is For</strong></p> <p>System administrators, IT personnel, incident response teams, forensic investigators, professors teaching in undergraduate and graduate programs in cybersecurity, students in cybersecurity and computer science programs, and software developers and engineers developing new cybersecurity defenses</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 5,469円

Air Force Targeting Roadmap: Reinvigorating Targeting, Reachback and Distributed Operations, Systems, Tools, Architectures, Training, Force Management, Precision Munition Bombing Air Campaign【電子書籍】[ Progressive Management ]

楽天Kobo電子書籍ストア
<p>Professionally converted for accurate flowing-text e-book format reproduction, this unique study address issues with Air Force targeting.</p> <p>Targeting is a core competency of the USAF. However, the capability and capacity to adequately conduct deliberate planning and support air operations has atrophied. At the 2012 CORONA South conference, the senior leadership of the Air Force acknowledged that there is insufficient targeting capacity. The Secretary of the Air Force (SecAF) and Chief of Staff of the Air Force (CSAF) directed the development of this roadmap as part of a larger plan to reinvigorate Air Force targeting. The Air Force Targeting Roadmap (AFTRM) was developed to address long-standing issues within Air Force targeting related to a decreasing capability to provide effective and efficient targeting support. Combining the findings from numerous studies, the strategy and risks outlined in the Global Integrated Intelligence, Surveillance, and Reconnaissance Core Function Master Plan (GIISR CFMP), targeting related equities and concerns in the Command and Control, Global Precision Attack, Agile Combat System, Space Superiority, and Cyberspace Superiority CFMPs, and recent real-world events, stakeholders across the Air Force identified the most critical deficiencies to effective targeting support for Air Force Component warfighting operations. These deficiencies were grouped into five major focus areas: targeting requirements and production capacity; reachback and distributed operations; systems, tools and architectures; training; and force management. Those deficiencies, in turn, have associated short-, mid-, and long-term actions that must be taken to reinvigorate Air Force targeting and put our Service back on the path to effectively and efficiently employ airpower to support our nation's security. Meeting the following objectives will address the identified deficiencies:</p> <p>Establish an efficient Air Force targeting requirements process and increase production capacity needed to support air component targeting requirements; Enable efficient and reliable reachback and distributed operations; Build a standardized, interoperable set of systems, tools and architecture; Reinvigorate Air Force targeting through education and training; Improve force management processes.</p> <p>The Air Force Targeting Roadmap provides fundamental guidance on how to better organize, train, equip, conduct, and manage our targeting and targeting-related personnel and resources to ensure efficient and effective targeting operations during peacetime, contingency, and war.</p> <p>Executive Summary * Chapter 1: Introduction * 1.0. Purpose of the Air Force Targeting Roadmap * 1.1. Background * 1.2. The Air Force Targeting Enterprise * 1.3. Objectives of the Air Force Targeting Roadmap * 1.4. Roadmap Organization * 1.5. Roadmap Development Process * Chapter 2: Targeting Requirements and Production Capacity * 2.0. Introduction * 2.1. Problem Statement * 2.2. Desired End State * 2.3. Root Causes * 2.4. Actions * Chapter 3: Reachback and Distributed Operations * 3.0 Introduction * 3.1. Problem Statement * 3.2. Desired End State * 3.3. Root Causes * 3.4. Actions * Chapter 4: Systems, Tools, and Architectures * 4.0. Introduction * 4.1. Problem Statement * 4.2. Desired End State * 4.3. Root Causes * 4.4. Actions * Chapter 5: Education and Training * 5.0. Introduction * 5.1. Problem Statement * 5.2. Desired End State * 5.3. Root Causes * 5.4. Actions * Chapter 6: Force Management * 6.0. Introduction * 6.1. Problem Statement * 6.2. Desired End State * 6.3. Root Causes * 6.4. Actions * Summary and Way Ahead * Appendix 1 * Terms of Reference * Appendix 2 * "Top 5" Targeting Issues * Appendix 3 * Roadmap Development Methodology * Appendix 4 * Glossary * Appendix 5 * Reference Documents</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 1,180円

Targeting Treatment of Soft Tissue Sarcomas【電子書籍】

楽天Kobo電子書籍ストア
<p>Recent achievements in the development of new techniques and agents for the treatment of cancer in general as well as for soft tissue sarcomas are tremendous. Molecular biology research has changed the landscape considerably and an increasing number of subtypes of soft tissue sarcomas are related to changes in cellular growth factors in the cell signaling pathways. This enables the development of targeted agents with specific activity against these factors. The presence of the KIT receptor at the surface of the gastrointestinal stroma tumor cell, and the activation constituted by mutations has led to the discovery of an extremely active specific KIT tyrosine kinase inhibitor.</p> <p>In accordance with the more targeted approach in drug use, the changes in the field of radiation therapy and surgery basically focus on a better targeting of the disease, albeit not yet based on the molecular characteristics. All of these stress the importance of the multidisciplinary approach to the treatment of soft tissue sarcoma that was the focus of previous editions of this book.</p> <p><strong>Targeting Treatment of Soft Tissue Sarcomas</strong> summarizes the recent events in this field, putting the achievements in perspective. Physicians and researchers working in the field of soft tissue sarcomas must be aware of the changes in treatment, the underlying concepts, and of the changes we face in the future.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 6,076円

From Morphological Imaging to Molecular Targeting Implications to Preclinical Development【電子書籍】

楽天Kobo電子書籍ストア
画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 18,231円

Targeting Epigenetics in Inflammatory Lung Diseases【電子書籍】

楽天Kobo電子書籍ストア
<p>This book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation?related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 19,447円

Novel Therapeutic Approaches Targeting Oxidative Stress【電子書籍】

楽天Kobo電子書籍ストア
<p><em>Novel Therapeutic Approaches Targeting Oxidative Stress</em> investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored.</p> <p>The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives.</p> <ul> <li>Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer</li> <li>Covers a range of therapeutic approaches to target oxidative stress</li> <li>Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress</li> <li>Features case studies illustrating the targeting of oxidative stress</li> </ul>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 16,313円

Modern Media Targeting A Complete Guide - 2019 Edition【電子書籍】[ Gerardus Blokdyk ]

楽天Kobo電子書籍ストア
<p>What practices helps your organization to develop its capacity to recognize patterns? How do you measure success? What are the timeframes required to resolve each of the issues/problems? How can you reduce costs? What defines best in class?</p> <p>Defining, designing, creating, and implementing a process to solve a challenge or meet an objective is the most valuable role… In EVERY group, company, organization and department.</p> <p>Unless you are talking a one-time, single-use project, there should be a process. Whether that process is managed and implemented by humans, AI, or a combination of the two, it needs to be designed by someone with a complex enough perspective to ask the right questions. Someone capable of asking the right questions and step back and say, 'What are we really trying to accomplish here? And is there a different way to look at it?'</p> <p>This Self-Assessment empowers people to do just that - whether their title is entrepreneur, manager, consultant, (Vice-)President, CxO etc... - they are the people who rule the future. They are the person who asks the right questions to make Modern Media Targeting investments work better.</p> <p>This Modern Media Targeting All-Inclusive Self-Assessment enables You to be that person.</p> <p>All the tools you need to an in-depth Modern Media Targeting Self-Assessment. Featuring 942 new and updated case-based questions, organized into seven core areas of process design, this Self-Assessment will help you identify areas in which Modern Media Targeting improvements can be made.</p> <p>In using the questions you will be better able to:</p> <p>- diagnose Modern Media Targeting projects, initiatives, organizations, businesses and processes using accepted diagnostic standards and practices</p> <p>- implement evidence-based best practice strategies aligned with overall goals</p> <p>- integrate recent advances in Modern Media Targeting and process design strategies into practice according to best practice guidelines</p> <p>Using a Self-Assessment tool known as the Modern Media Targeting Scorecard, you will develop a clear picture of which Modern Media Targeting areas need attention.</p> <p>Your purchase includes access details to the Modern Media Targeting self-assessment dashboard download which gives you your dynamically prioritized projects-ready tool and shows your organization exactly what to do next. You will receive the following contents with New and Updated specific criteria:</p> <p>- The latest quick edition of the book in PDF</p> <p>- The latest complete edition of the book in PDF, which criteria correspond to the criteria in...</p> <p>- The Self-Assessment Excel Dashboard</p> <p>- Example pre-filled Self-Assessment Excel Dashboard to get familiar with results generation</p> <p>- In-depth and specific Modern Media Targeting Checklists</p> <p>- Project management checklists and templates to assist with implementation</p> <p>INCLUDES LIFETIME SELF ASSESSMENT UPDATES</p> <p>Every self assessment comes with Lifetime Updates and Lifetime Free Updated Books. Lifetime Updates is an industry-first feature which allows you to receive verified self assessment updates, ensuring you always have the most accurate information at your fingertips.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 5,766円

洋書 Advanced Customer Analytics: Targeting, Valuing, Segmenting and Loyalty Techniques (Marketing Science)

Glomarket
*** We ship internationally, so do not use a package forwarding service. We cannot ship to a package forwarding company address because of the Japanese customs regulation. If it is shipped and customs office does not let the package go, we do not make a refund. 【注意事項】 *** 特に注意してください。 *** ・個人ではない法人・団体名義での購入はできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 ・お名前にカタカナが入っている場合法人である可能性が高いため当店システムから自動保留します。カタカナで記載が必要な場合はカタカナ変わりローマ字で記載してください。 ・お名前またはご住所が法人・団体名義(XX株式会社等)、商店名などを含めている場合、または電話番号が個人のものではない場合、税関から法人名義でみなされますのでご注意ください。 ・転送サービス会社への発送もできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 *** ・注文後品切れや価格変動でキャンセルされる場合がございますので予めご了承願います。 ・当店でご購入された商品は、原則として、「個人輸入」としての取り扱いになり、すべてニュージャージからお客様のもとへ直送されます。 ・ご注文後、30営業日以内(通常2~3週間)に配送手続きをいたします。配送作業完了後、2週間程度でのお届けとなります。 ・まれに商品入荷状況や国際情勢、運送、通関事情により、お届けが2ヶ月までかかる場合がありますのでお急ぎの場合は注文をお控えください。 ・個人輸入される商品は、すべてご注文者自身の「個人使用・個人消費」が前提となりますので、ご注文された商品を第三者へ譲渡・転売することは法律で禁止されております。 ・関税・消費税が課税される場合があります。詳細はこちらをご確認下さい。PC販売説明文 7,128円

21st Century U.S. Military Manuals: Army Tactical Human Intelligence and Counterintelligence Operations ST 2-22.7 (FM 34-7-1) - HUMINT in Urban Environment, Battlefield, Command and Control, Team Operations, Targeting【電子書籍】

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<p>This important U.S. Army document, the Tactical Human Intelligence and Counterintelligence Operations manual, has been professionally converted for accurate flowing-text e-book format.</p> <p>Contents: CHAPTER 1 TACTICAL HUMAN INTELLIGENCE COLLECTION ASSETS * HUMINT and CI Interaction * Human Intelligence * Counterintelligence * What is Tactical HUMINT? * HUMINT and CI Operations on the Battlefield * HUMINT and CI Operations Within the Urban Environment * Army HUMINT and CI Organizations * Other Sources of HUMINT on the Battlefield * CHAPTER 2 ORGANIZATION AND STRUCTURE * Tactical HUMINT Organization * J/G/S2X * CHAPTER 3 COMMAND AND CONTROL * Role of the MI Commander * Command Relationships * Support Relationships * Technical Control * Reporting * CHAPTER 4 COLLECTION ACTIVITIES * Collection Methodology * Operations * Human Sources * Other Sources * CHAPTER 5 TEAM OPERATIONS * Concentric Rings Operation Methodology * Levels of Employment * Equipment Requirements * Tactics, Techniques, and Procedures * CHAPTER 6 HUMINT AND CI MISSION PLANNING * Steps in HUMINT and CI Mission Analysis * Selecting Courses of Action * Task Organization * Operations Plans, Operations Orders, and Annexes * CHAPTER 7 HUMINT AND CI COLLECTION MANAGEMENT * Collection Management Process * HUMINT and CI Support to Targeting * Control Measures * CHAPTER 8 AUTOMATION AND COMMUNICATIONS * Automation * Communications</p> <p>This manual establishes the initial doctrinal foundation for Tactical HUMINT Operations. It provides the basis for the organization and structure of tactical HUMINT operations from peacetime military engagements (PME) to major theater war (MTW).<br /> This manual is designed primarily for the commanders and soldiers of units conducting tactical HUMINT collection. It can also be used by commanders, staffs, and intelligence personnel at all echelons, and applies equally to Active Components (AC) and Reserve Components (RC), to include US Army Reserves (USAR) and the Army National Guard (ARNG).</p> <p>Timely and accurate intelligence derived from human intelligence (HUMINT) and counterintelligence (CI) assets is critical to the military decision-making process (MDMP). Despite the array of intelligence sensors, recent operations have shown that a local population is a key element in most operational planning. The early and continuous contact by HUMINT collectors and CI agents with the civilian population is often the best source of information about the area of operations (AO). Understanding the capabilities and limitations of this collection system is vital to operational planning and execution in operations from peacetime military engagements (PME) to major theater war (MTW).</p> <p>This compilation includes a reproduction of the 2019 Worldwide Threat Assessment of the U.S. Intelligence Community.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 637円

Targeting Guns Firearms and Their Control【電子書籍】[ Gary Kleck ]

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<p>This new paperback comprehensively reviews the research evidence on the links between guns, violence, and gun control, and reports results of the author's own research as well. In Targeting Guns, Kleck follows the line of argument and careful statistical inference of his earlier prizewinning volume, Point Blank, while updating the literature reviews and statistical information, and adding two chapters.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 7,877円

Immunotherapy in 2020 Visions and Trends for Targeting Inflammatory Disease【電子書籍】

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画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 6,076円

Wild Mustang Woman and Targeting the Deputy WILD MUSTANG WOMAN & TARGETING [ Lindsay McKenna ]

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WILD MUSTANG WOMAN & TARGETING Lindsay McKenna Delores Fossen HARLEQUIN SALES CORP2023 Mass Market Paperbound Reissue English ISBN:9781335662521 洋書 Fiction & Literature(小説&文芸) Fiction 1,584円

Targeting ブルーレイ 【輸入盤】

WORLD DISC PLACE
◆タイトル: Targeting◆現地発売日: 2017/02/07◆レーベル: Indie Rights◆その他スペック: オンデマンド生産盤**フォーマットは基本的にCD-R等のR盤となります。 輸入盤DVD/ブルーレイについて ・日本語は国内作品を除いて通常、収録されておりません。・ご視聴にはリージョン等、特有の注意点があります。プレーヤーによって再生できない可能性があるため、ご使用の機器が対応しているか必ずお確かめください。詳しくはこちら ◆収録時間: 85分※商品画像はイメージです。デザインの変更等により、実物とは差異がある場合があります。 ※注文後30分間は注文履歴からキャンセルが可能です。当店で注文を確認した後は原則キャンセル不可となります。予めご了承ください。A dark indie drama/thriller about a female soldier returning from Afghanistan who begins running surveillance on an Afghan person-of-interest she learns is living in her hometown.Targeting ブルーレイ 【輸入盤】 4,133円

Targeting Top Terrorists Understanding Leadership Removal in Counterterrorism Strategy【電子書籍】[ Lt. Col. Bryan C. Price ]

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<p>When President Barack Obama announced the assassination of Osama bin Laden, many Americans hoped the killing of al-Qaida’s leader would sound the death knell for the organization. Since 9/11, killing and capturing terrorist leaders has been a central element in U.S. counterterrorism strategy. This practice, known as leadership decapitation, is based on the logic that removing key figures will disrupt the organization and contribute to its ultimate failure. Yet many scholars have argued that targeted killings are ineffective or counterproductive, questioning whether taking out a terror network’s leaders causes more problems than it solves.</p> <p>In <em>Targeting Top Terrorists</em>, Bryan C. Price offers a rich, data-driven examination of leadership decapitation tactics, providing theoretical and empirical explanations of the conditions under which they can be successful. Analyzing hundreds of cases of leadership turnover from over two hundred terrorist groups, Price demonstrates that although the tactic may result in short-term negative side effects, the loss of top leaders significantly reduces terror groups’ life spans. He explains vital questions such as: What factors make some terrorist groups more vulnerable than others? Is it better to kill or capture terrorist leaders? How does leadership decapitation compare to other counterterrorism options? With compelling evidence based on an original dataset along with an in-depth case study of Hamas, <em>Targeting Top Terrorists</em> contributes to scholarship on terrorism and organizational theory and provides insights for policy makers and practitioners on some of the most pressing debates in the field.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 3,417円

Cain’s Crime The Proliferation of Weapons and the Targeting of Civilians in Contemporary War【電子書籍】[ Thomas Trzyna ]

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<p>Democracy requires a commitment to dialogue and deliberation, as well as a commitment to seek peaceful solutions. Is democracy possible in states that earn significant portions of their revenue from the manufacture and sales of arms, that give weapons away in huge numbers, and that turn quickly to violence in the face of difficulties? The proliferation of weapons is nearly as great a tragedy of the commons as global warming, and the evidence indicates that civilians are increasingly being targeted in wars. How large is the problem of war today? Given that the members of the UN Security Council are among the chief manufacturers of weapons, are there any useful mechanisms in place for limiting wars or the supply of deadly weapons? Is it time, in view of the callousness with which non-combatants are killed, to re-examine our basic reasons for valuing human life? Cain's Crime re-introduces an ethical theory popular at the dawn of the twentieth century and examines the extent of violence in the contemporary world, from neo-colonial wars, civil wars, freedom movements, and ethnic conflicts to the oldest war of all, the systematic and continuing murder of women in cultures where they are valued less than men.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 1,923円

Chemical Biology Approaches to Drug Discovery and Development to Targeting Disease【電子書籍】[ Natanya Civjan ]

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<p><em><strong>An authoritative look at the application of chemical biology in drug discovery and development</strong></em></p> <p>Based on the award-winning <em>Wiley Encyclopedia of Chemical Biology</em> published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases.</p> <p>Comprising carefully selected reprints from the <em>Encyclopedia</em> as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including:</p> <ul> <li>The design, development, and optimization of drug candidates</li> <li>The pharmacokinetics and properties of drugs</li> <li>Drug transport and delivery</li> <li>Natural products and natural product models as pharmaceuticals</li> <li>Biological mechanisms underlying health and disease</li> <li>Treatment strategies for a range of diseases, from HIV to schizophrenia</li> </ul> <p><em>Chemical Biology</em> is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 17,324円

Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting【電子書籍】[ Tamilvanan Shunmugaperumal ]

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<p>This book combines emulsion knowledge into a single, comprehensive volume, ideal for professionals and students involved in the areas of pharmaceutical science who are looking to learn about this emergent research concept.</p> <ul> <li>Compiles the step-by-step investigations made concerning the potential of nanosized emulsions on both drug delivery and drug targeting areas by different group of scientists in various laboratories across the world</li> <li>Inverts the common nano-emulsions coverage trend of focusing on focused on the particulate system itself, instead exploring the way to turn nanosized emulsions as biomedical tool, as well as, treating the in vitro and in vivo aspects after administration</li> <li>Provides an overview of the current state-of-the art regarding the development of tocol emulsions, emulsion adjuvants in immunization research, oxygen-carrying emulsions (called as fluorocarbon emulsion) and emulsions for delivering drugs to nasal and topical (ocular and transdermal) routes</li> </ul>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 29,179円

Drug Discovery Targeting Drug-Resistant Bacteria【電子書籍】

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<p><em>Drug Discovery Targeting Drug-Resistant Bacteria</em> explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included.</p> <p>Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful.</p> <ul> <li>Written by scientists with extensive industrial experience in drug discovery</li> <li>Provides a balanced view of the field, including its challenges and future directions</li> <li>Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war</li> </ul>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 19,773円

Nanomaterials For Tumor Targeting Theranostics: A Proactive Clinical Perspective【電子書籍】[ Mingqian Tan ]

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<p>Nanomaterials offer great potential for effective tumor diagnosis and therapy combing diagnostic agents and therapeutic drugs into one platform. In this book, the most recent progress of main nanomaterials and their applications in tumor targeting theranostics is presented. It summarizes the recent advances of current principal nanomaterials in tumor theranostics, including magnetic nanomaterials, quantum dots, mesoporous silica nanoparticles, gold nanomaterials, polymeric nanosystem, carbon nanomaterials, lipopolyplex nanoparticles, microbubbles, upconversion nanomaterials and dendrimers. It will enable readers to get a more realistic understanding of both the advantages and limitations of nanomaterials for potential tumor targeting theranosis. The publication of this book will accelerate the spread of ideas that are currently trickling through the scientific literature. Also a greater understanding of the potential and challenge of nanomaterials for tumor targeting theranostics is highly anticipated for practical clinical use.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 7,491円

Targeting: The Challenges of Modern Warfare【電子書籍】

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<p>This book offers a multidisciplinary treatment of targeting. It is intended for use by the military, government legal advisers and academics. The book is suitable for use in both military training and educational programs and in Bachelor and Master degree level courses on such topics as War Studies and Strategic Studies.</p> <p>The book first explores the context of targeting, its evolution and the current targeting process and characteristics. An overview of the legal and ethical constraints on targeting as an operational process follows. It concludes by surveying contemporary issues in targeting such as the potential advent of autonomous weapon systems, ‘non-kinetic’ targeting, targeting in multinational military operations and leadership decapitation in counter-terrorism operations.</p> <p>The deep practical experience and academic background of the contributors ensures comprehensive treatment of current targeting and use of force issues.</p> <p><strong>Paul Ducheine</strong> is Professor for Cyber Operations and Cyber Security, Netherlands Defence Academy, Breda, The Netherlands; and Professor of Law of Military Cyber Operations and Cyber Security at the University of Amsterdam, The Netherlands. <strong>Michael Schmitt</strong> is Charles H. Stockton Professor & Director, Stockton Center for the Study of International Law, U.S. Naval War College, Newport, Rhode Island, and Professor of Public International Law, University of Exeter, UK. <strong>Frans Osinga</strong> isChair of the War Studies Department, Netherlands Defence Academy, Breda, The Netherlands, and Professor of Military Operational Art and Sciences.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 20,661円

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins【電子書籍】[ Raphael Enoque Ferraz de Paiva ]

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<p>This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C?S coupling.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 12,154円

Drugs Targeting B-Cells in Autoimmune Diseases【電子書籍】

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<p>This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sj?gren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。 18,231円

【中古】[CD]TARGETING ZONES

IINEX
【中古】[CD]TARGETING ZONES【メーカー名】【メーカー型番】【ブランド名】Bad News【商品説明】TARGETING ZONESこちらの商品は中古品となっております。 画像はイメージ写真ですので 商品のコンディション・付属品の有無については入荷の度異なります。 買取時より付属していたものはお付けしておりますが付属品や消耗品に保証はございません。 商品ページ画像以外の付属品はございませんのでご了承下さいませ。 中古品のため使用に影響ない程度の使用感・経年劣化(傷、汚れなど)がある場合がございます。 また、中古品の特性上ギフトには適しておりません。 当店では初期不良に限り 商品到着から7日間は返品を受付けております。 他モールとの併売品の為 完売の際はご連絡致しますのでご了承ください。 プリンター・印刷機器のご注意点 インクは配送中のインク漏れ防止の為、付属しておりませんのでご了承下さい。 ドライバー等ソフトウェア・マニュアルはメーカーサイトより最新版のダウンロードをお願い致します。 ゲームソフトのご注意点 特典・付属品・パッケージ・プロダクトコード・ダウンロードコード等は 付属していない場合がございますので事前にお問合せ下さい。 商品名に「輸入版 / 海外版 / IMPORT 」と記載されている海外版ゲームソフトの一部は日本版のゲーム機では動作しません。 お持ちのゲーム機のバージョンをあらかじめご参照のうえ動作の有無をご確認ください。 輸入版ゲームについてはメーカーサポートの対象外です。 DVD・Blu-rayのご注意点 特典・付属品・パッケージ・プロダクトコード・ダウンロードコード等は 付属していない場合がございますので事前にお問合せ下さい。 商品名に「輸入版 / 海外版 / IMPORT 」と記載されている海外版DVD・Blu-rayにつきましては 映像方式の違いの為、一般的な国内向けプレイヤーにて再生できません。 ご覧になる際はディスクの「リージョンコード」と「映像方式※DVDのみ」に再生機器側が対応している必要があります。 パソコンでは映像方式は関係ないため、リージョンコードさえ合致していれば映像方式を気にすることなく視聴可能です。 商品名に「レンタル落ち 」と記載されている商品につきましてはディスクやジャケットに管理シール(値札・セキュリティータグ・バーコード等含みます)が貼付されています。 ディスクの再生に支障の無い程度の傷やジャケットに傷み(色褪せ・破れ・汚れ・濡れ痕等)が見られる場合がありますので予めご了承ください。 2巻セット以上のレンタル落ちDVD・Blu-rayにつきましては、複数枚収納可能なトールケースに同梱してお届け致します。 トレーディングカードのご注意点 当店での「良い」表記のトレーディングカードはプレイ用でございます。 中古買取り品の為、細かなキズ・白欠け・多少の使用感がございますのでご了承下さいませ。 再録などで型番が違う場合がございます。 違った場合でも事前連絡等は致しておりませんので、型番を気にされる方はご遠慮ください。 ご注文からお届けまで 1、ご注文⇒ご注文は24時間受け付けております。 2、注文確認⇒ご注文後、当店から注文確認メールを送信します。 3、お届けまで3-10営業日程度とお考え下さい。  ※海外在庫品の場合は3週間程度かかる場合がございます。 4、入金確認⇒前払い決済をご選択の場合、ご入金確認後、配送手配を致します。 5、出荷⇒配送準備が整い次第、出荷致します。発送後に出荷完了メールにてご連絡致します。  ※離島、北海道、九州、沖縄は遅れる場合がございます。予めご了承下さい。 当店ではすり替え防止のため、シリアルナンバーを控えております。 万が一すり替え等ありました場合は然るべき対応をさせていただきます。 お客様都合によるご注文後のキャンセル・返品はお受けしておりませんのでご了承下さい。 電話対応はしておりませんので質問等はメッセージまたはメールにてお願い致します。 3,480円