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商品	説明	価格
Oxidative Stress and Redox Signalling in Parkinson’s Disease【電子書籍】楽天Kobo電子書籍ストア	＜p＞Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis.＜br /＞ This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics.＜br /＞ Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant ? based therapeutics for Parkinson’s disease.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	28,489円
Peroxiporins Redox Signal Mediators In and Between Cells【電子書籍】楽天Kobo電子書籍ストア	＜p＞To produce energy, aerobic organisms transform oxygen molecules into water. This reductive mechanism yields toxic radical intermediates, collectively known as reactive oxygen species (ROS). Paradoxically, these physiological processes entail the production of potentially damaging species. Evolution has turned this apparent disadvantage into an opportunity for transmitting information. As a result, redox signaling within the cell is an efficient exquisitely organized process. A key element for its regulation is the physical separation of sources and targets into different cell compartments. Peroxiporins, H2O2 transporting proteins spanning biological membranes, distribute the signal from emitters to receptors. Thus, these channels are strategically situated in the thin line between life and death, guaranteeing adequate but safe signaling.＜/p＞＜p＞＜strong＞Key Features:＜/strong＞＜/p＞＜p＞- Provides a brief history of the discovery and characterization of peroxiporins＜br /＞ - Reviews key findings on hydrogen peroxide transport across biological membranes＜br /＞ - Discusses the cartography of redox signaling in crowded cells＜br /＞ - Includes lavish illustrations and comprehensive images to facilitate teaching＜br /＞ - Highlights recent findings, outstanding controversies and open questions＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	8,945円
Redox Signaling and Biomarkers in Ageing【電子書籍】楽天Kobo電子書籍ストア	＜p＞This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book.＜/p＞＜p＞Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ? and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers.＜/p＞＜p＞Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients.＜/p＞＜p＞This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	17,016円
What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology【電子書籍】[ Adam Thomas Brockett ] 楽天Kobo電子書籍ストア	＜p＞＜em＞What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, Volume 158＜/em＞ addresses and highlights a question that has remained central to cognitive and systems neuroscience since its inception, namely, what does the medial frontal cortex do? With insights from 17 of the fields leading teams of scientists, this volume attempts to address this question covering several topics with chapters including What do single unit responses in dorsal anterior cingulate cortex mean?, Social Processing by the Primate Medial Frontal Cortex, Medial frontal cortex and the temporal control of action, The midcingulate cortex and temporal integration, and more.＜/p＞＜p＞Additional chapters cover The anterior cingulate cortex and event-based modulation of autonomic states, Integration of value and action in medial prefrontal neural systems, Secondary motor cortex: broadcasting and biasing animal’s decisions through long-range circuits, The prefrontal cortex in social cognition, Representing task strategies in the medial prefrontal cortex, Prefrontal contributions to action control in rodents, From affective to cognitive processings: functional organization of the medial frontal cortex, and much more.＜/p＞＜ul＞＜li＞Comprises the perspectives of a diverse array of world-leading researchers in medial frontal cortex function＜/li＞＜li＞Provides the latest theoretical and data-based evidence for the function of medial frontal cortex＜/li＞＜li＞Presents the importance of systems-based neuroscience approaches to the understanding of medial frontal cortex function＜/li＞＜/ul＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	24,426円
Pulmonary Vasculature Redox Signaling in Health and Disease【電子書籍】楽天Kobo電子書籍ストア	＜p＞The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field.＜/p＞＜p＞The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	18,231円
Oxidative Stress and Redox Signalling in Parkinson's Disease OXIDATIVE STRESS & REDOX SIGNA （Issues in Toxicology） [ Rodrigo Franco ] 楽天ブックス	OXIDATIVE STRESS & REDOX SIGNA Issues in Toxicology Rodrigo Franco Jonathan A. Doorn JeanーChristophe Rochet ROYAL SOCIETY OF CHEMISTRY2017 Hardcover English ISBN：9781782621881 洋書 Computers & Science（コンピューター＆科学） Medical	64,046円
Will Planet X Signal the Rapture?【電子書籍】[ David Meade ] 楽天Kobo電子書籍ストア	＜p＞My inspiration for this book was a vision that I'm aware of where it was revealed that in October of 2017 (I know the day but I'd rather not mention it at this point, but it is in October and in the very latter part) that Russia, China and North Korea would use a combination of drone submarines and unmarked container ships to engage in a nuclear attack on the US coast. The attack will occur between midnight and dawn, and they will attack both Britain and the U.S. simultaneously. God told him that as soon as the missiles appeared on the horizon, the rapture of the church would occur.＜/p＞＜p＞The Russians are planning this at a compartmentalized, high and secret level, and the reason for the date they have chosen is that it commemorates the 100th anniversary of the Russian Revolution. Afterwards, with Israel's protectors neutralized, they will invade the Middle East as Israel has a warm water port and the largest oil and gas fields on the planet (now known as the Leviathan gas fields).＜/p＞＜p＞The book, chapter by chapter, goes into the Biblical basis for this event and its precise timing. It explains what will happen afterwards. It most of all explains how an astronomical object, called by some Nibiru and also known as Planet X, will create the very environment from which such events occur.＜/p＞画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちらをクリックして下さい。 ※このページからは注文できません。	399円