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1602件中 1件 - 30件
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商品 | 説明 | 価格 |
Coordinating Public and Private Sustainability Green Energy Policy, International Trade Law, and Economic Mechanisms【電子書籍】[ Roy Partain ]
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<p>This book demonstrates the need to coordinate private and corporate actors with national and global sustainable climate policies, with conventions in the spheres of green energy laws, as well as from the spheres of commercial, trade, and other private law.</p> <p>While many states have joined together in the Paris Agreements in support of green energy policies, it remains a stark reality that most of the efforts to reduce greenhouse emissions remain with private actors who operate the various industries, vehicles, and vessels that emit the gases in target. The risks of anthropogenic climate change cannot be solved by environmental law alone and will need complementary support from commercial, corporate, and private law. However, aspects of commercial law, securities law, and trade law can be shown to frustrate certain aspects of green energy policies, resulting in damaging "green paradoxes". It raises issues associated with corporate social responsibility and green paradoxes, with international trade laws, and with liability risks for misrepresenting the state of feasible green energy technologies.</p> <p>The book will be of interest to students and scholars in the fields of energy law, environmental law, and corporate law.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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9,285円
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Mechanisms of DNA Recombination and Genome Rearrangements: Intersection Between Homologous Recombination, DNA Replication and DNA Repair【電子書籍】[ Maria Spies ]
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<p><em>Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair, Volume 601</em>*,* the latest release in the <em>Methods in Enzymology</em> series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.</p> <p>Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination. The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.</p> <ul> <li>contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability</li> <li>documents cutting edge methods</li> </ul>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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23,145円
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Agricultural robots mechanisms and Practice [ 近藤直 ]
楽天ブックス
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mechanisms and Practice 近藤直 門田充司 京都大学学術出版会アグリカルチュラル ロボッツ コンドウ,ナオシ モンタ,ミツジ 発行年月:2011年 ページ数:348p サイズ:単行本 ISBN:9784876985531 本 ビジネス・経済・就職 産業 農業・畜産業
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4,180円
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Neuroscience of Nicotine Mechanisms and Treatment【電子書籍】
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<p><em>Neuroscience of Nicotine: Mechanisms and Treatment</em> presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of nicotine addiction and its effects on the brain. Offering thorough coverage of all aspects of nicotine research, treatment, policy and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of nicotine misuse.</p> <p>With an estimated one billion individuals worldwide classified as tobacco usersーand tobacco use often being synonymous with nicotine addictionーnicotine is one of the world’s most common addictive substances, and a frequent comorbidity of misuse of other common addictive substances. Nicotine alters a variety of neurological processes, from molecular biology, to cognition, and quitting is exceedingly difficult because of the number of withdrawal symptoms that accompany the process.</p> <ul> <li>Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of nicotine use, along with its effects on neurobiological function</li> <li>Discusses nicotine use as a component of dual-use and poly addictions and outlines numerous screening and treatment strategies for misuse</li> <li>Covers both the physical and psychological effects of nicotine use and withdrawal to provide a fully-formed view of nicotine dependency and its effects</li> </ul>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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17,301円
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Mechanisms of Morphogenesis【電子書籍】[ Jamie A. Davies ]
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<p><em>Mechanisms of Morphogenesis, Third Edition</em> offers a bottom-up discussion of mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi. Across foundational, applied and methods-based chapters, this book examines molecular nano-machines cooperation, generate cell shape, direct cell migration, and shape, form and rates of growth of various tissues in the body. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and likely future developments, along with strategies to apply basic morphogenesis science across ever evolving applications.</p> <p>Newly added chapters feature case-study-driven discussions of morphogenesis in natural embryos and organoids, and illustrate how pathological morphogenesis can generate variants of body form. This edition has also been updated with analysis of large-scale and scale-invariant mechanisms, for example, morphogenesis by differential growth in mechanically connected tissues.</p> <ul> <li>Includes over 200 full color figures and charts</li> <li>Offers an integrated view of theoretical developmental biology and computer modeling with laboratory-based discoveries</li> <li>Includes applied, case-study-driven discussion of experimental techniques</li> <li>Is organized around principles and mechanisms, using them to integrate discoveries from a range of organisms and systems across new applications</li> <li>Covers recent developments in morphogenesis research, including morphogenesis in organoids, other engineered tissues, and an analysis of large-scale and scale-invariant mechanisms</li> </ul>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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14,830円
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Molecular Mechanisms of Photosynthesis【電子書籍】[ Robert E. Blankenship ]
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<p>MOLECULAR MECHANISMS OF PHOTOSYNTHESIS</p> <p><strong>Rediscover the foremost introduction to molecular photosynthesis on the market today</strong></p> <p>In the comprehensively revised Third Edition of <em>Molecular Mechanisms of Photosynthesis</em>, distinguished researcher and professor Robert E. Blankenship delivers a brand-new update to the most authoritative textbook on the subject of photosynthesis. In addition to thorough coverage of foundational topics in photosynthesis, the book discusses cutting-edge advances in research in this area, including new structures and new information about the mechanism of oxygen production.</p> <p>The author also describes advancements in the understanding of the regulation of photosynthesis and the critical process of photoprotection, as well as newly discovered pigments and organisms that extend oxygenic photosynthesis deeper into the near infrared spectral region.</p> <p>Readers will also benefit from the inclusion of a fulsome appendix that incorporates a detailed introduction to the physical basis of photosynthesis, including thermodynamics, kinetics, and spectroscopy. A companion website offers downloadable figures as PowerPoint slides ideal for teaching. The book also includes:</p> <ul> <li>Thorough introductions to the basic principles of photosynthetic energy storage, photosynthetic organisms and organelles, and the history and early development of photosynthesis</li> <li>An expansive discussion of photosynthetic pigments, including their structure and spectroscopy</li> <li>Explorations of antenna complexes, energy transfer processes, reaction centers, and electron transport pathways in anoxygenic phototrophs and oxygenic photosynthetic organisms</li> <li>Comprehensive treatments of chemiosmotic coupling, ATP synthesis, and carbon metabolism</li> <li>Authoritative discussions of the evolution of photosynthesis and artificial photosynthesis</li> </ul> <p>Perfect for advanced undergraduate and beginning graduate students in biochemistry and biophysics, <em>Molecular Mechanisms of Photosynthesis</em> will also earn a place in the libraries of students studying plant biology and seeking a one-stop resource in the field of molecular photosynthesis.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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9,826円
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Command And Control Mechanisms In The Chickamauga Campaign: The Union Experience【電子書籍】[ Major Philip J. Baker Jr. ]
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<p>This thesis analyzes how Major General William S. Rosecrans, commander of the Army of the Cumberland, employed the command and control mechanisms available to him as he maneuvered his army from Tullahoma, Tennessee toward Chattanooga, Tennessee in August-September, 1863. It also analyzes how these mechanisms were employed during the battle of Chickamauga itself, on 19-20 September, 1863.</p> <p>General Rosecrans possessed three mechanisms for commanding and controlling his army. The first was the military telegraph, provided by the quasi-military U.S. Military Telegraph service. Next were the assets of the fledgling U.S. Signal Corps, which consisted of signal flags and torches, and a portable version of the telegraph. Finally, there were couriers, who were usually mounted, and were provided by subordinate unit details, or by units specifically formed for courier duty.</p> <p>The thesis concludes that General Rosecrans did not use his command and control mechanisms effectively. Rosecrans relied too heavily on couriers to carry messages over densely wooded, cross-compartmented terrain in order to send orders to his widely dispersed subordinates and receive information from them. While Rosecrans made wide use of the military telegraph, to include using it during the battle itself, he did not effectively use his Signal Corps assets. These assets were used essentially as static observation posts, and only to a limited degree as a means for effecting command and control.</p> <p>The thesis further concludes, however, that General Rosecrans use of command and control assets was not a decisive factor in the outcome of the campaign or battle. While his reliance upon courier assets added significantly to the time required to obtain information and send orders, it was not the reason for the Union defeat at Chickamauga.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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167円
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The Cambridge Handbook of Prosociality Development, Mechanisms, Promotion【電子書籍】
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<p>Prosociality is a multifaceted concept referring to the many ways in which individuals care about and benefit others. Human prosociality is foundational to social harmony, happiness, and peace; it is therefore essential to understand its underpinnings, development, and cultivation. This handbook provides a state-of-the-art, in-depth account of scientific, theoretical, and practical knowledge regarding prosociality and its development. Its thirty chapters, written by international researchers in the field, elucidate key issues, including: the development of prosociality across infancy, childhood, adolescence, and beyond; the biological, cognitive, emotional, and motivational mechanisms that underlie and influence prosociality; how different socialization agents and social contexts can affect children's prosociality; and intervention approaches aimed at cultivating prosociality in children and adolescents. This knowledge can benefit researchers, students, practitioners, and policy makers seeking to nurture socially responsible, caring youth.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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8,503円
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Hyperbole and a Half Unfortunate Situations, Flawed Coping Mechanisms, Mayhem, and Other Things That Happened【電子書籍】[ Alexandra Brosh ]
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<p><strong>Hilarious stories about life's mishaps from the creator of the immensely popular blog 'Hyperbole and a Half'. Fully illustrated with over 50% new material.</strong></p> <p><em>Hyperbole and A Half</em> is a blog and webcomic written by a 20-something American girl called Allie Brosh. She tells <strong>fantastically funny</strong>, wise stories about the <strong>mishaps of her everyday life</strong>, with titles like 'Why Dogs Don't Understand Basic Concepts Like Moving' and 'The God of Cake'..</p> <p>Brosh's website receives millions of visitors a month and hundreds of thousands per day. Now her <strong>full-colour debut book</strong> chronicles the many 'learning experiences' Brosh has endured as a result of her own character flaws. It includes stories about her rambunctious childhood; the highs and mostly lows of owning a mentally challenged dog; and a moving and darkly comic account of her struggles with depression.</p> <p><strong>'Quirky and captivating' <em>Observer</em></strong></p> <p><strong>'It's impossible not to warm to cartoonist and blogger Allie. If she doesn't get to you with her funny childhood anecdotes (eating an entire birthday cake) then her honest reflections on depression will' <em>Grazia</em></strong></p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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2,075円
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A Catechism of the Steam Engine Unveiling the Mechanisms: A Deep Dive into Steam Engine Technology and History【電子書籍】[ C.E. John Bourne ]
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<p>In 'A Catechism of the Steam Engine' by C.E. John Bourne, readers are taken on a comprehensive journey through the inner workings of steam engines. The book is written in a clear and straightforward manner, making complex concepts accessible to readers of all levels of expertise. Bourne's meticulous attention to detail and technical expertise shines through in his writing, providing readers with a thorough understanding of how steam engines operate. The book also serves as a valuable historical document, offering insights into the development of steam technology in the 19th century. Bourne's writing style is both informative and engaging, making this book a must-read for anyone interested in the history and mechanics of steam engines. C.E. John Bourne's background as an engineer and his passion for steam technology are evident in 'A Catechism of the Steam Engine.' His expertise in the field provides readers with a unique perspective on the topic, allowing them to delve deep into the intricacies of steam engine technology. I highly recommend this book to anyone looking to expand their knowledge of steam engines and their historical significance.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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310円
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Compliant Mechanisms Design of Flexure Hinges【電子書籍】[ Nicolae Lobontiu ]
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<p>With a rigorous and comprehensive coverage, the second edition of <em>Compliant Mechanisms: Design of Flexure Hinges</em> provides practical answers to the design and analysis of devices that incorporate flexible hinges. Complex-shaped flexible-hinge mechanisms are generated from basic elastic segments by means of a bottom-up compliance (flexibility) approach. The same compliance method and the classical finite element analysis are utilized to study the quasi-static and dynamic performances of these compliant mechanisms. This book offers easy-to-use mathematical tools to investigate a wealth of flexible-hinge configurations and two- or three-dimensional compliant mechanism applications.</p> <p>FEATURES</p> <ul> <li></li> <li>Introduces a bottom-up compliance-based approach to characterize the flexibility of new and existing flexible hinges of straight- and curvilinear-axis configurations</li> <li></li> <li>Develops a consistent linear lumped-parameter compliance model to thoroughly describe the quasi-static and dynamic behavior of planar/spatial, serial/parallel flexible-hinge mechanisms</li> <li></li> <li>Utilizes the finite element method to analyze the quasi-statics and dynamics of compliant mechanisms by means of straight- and curvilinear-axis flexible-hinge elements</li> <li></li> <li>Covers miscellaneous topics such as stress concentration, yielding and related maximum load, precision of rotation of straight- and circular-axis flexible hinges, temperature effects on compliances, layered flexible hinges and piezoelectric actuation/sensing</li> <li></li> <li>Offers multiple solved examples of flexible hinges and flexible-hinge mechanisms.</li> </ul> <p>This book should serve as a reference to students, researchers, academics and anyone interested to investigate precision flexible-hinge mechanisms by linear model-based methods in various areas of mechanical, aerospace or biomedical engineering, as well as in robotics and micro-/nanosystems.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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12,155円
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George Van Eps Harmonic Mechanisms for Guitar, Volume 2【電子書籍】[ George Van Eps ]
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<p>The most in-depth, revolutionary presentation of the harmonic framework of music as applied to the guitar fingerboard ever presented. Leads to total mastery of harmonic and technical aspects of the guitar.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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5,908円
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Calcitonin Gene-Related Peptide (CGRP) Mechanisms Focus on Migraine【電子書籍】
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<p>This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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12,154円
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Agent-Based Modeling of Social Conflict From Mechanisms to Complex Behavior【電子書籍】[ Carlos M. Lemos ]
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<p>This Brief revisits and extends Epstein’s classical agent-based model of civil violence by considering important mechanisms suggested by social conflict theories. Among them are: relative deprivation as generator of hardship, generalized vanishing of the risk perception (‘massive fear loss’) when the uprisings surpass a certain threshold, endogenous legitimacy feedback, and network influence effects represented by the mechanism of dispositional contagion. The model is explored in a set of computer experiments designed to provide insight on how mechanisms lead to increased complexity of the solutions. The results of the simulations are compared with statistical analyses of estimated size, duration and recurrence of large demonstrations and riots for eight African countries affected by the “Arab Spring,” based on the Social Conflict Analysis Database.</p> <p>It is shown that the extensions to Epstein’s model proposed herein lead to increased “generative capacity”of the agent-based model (i.e. a richer set of meaningful qualitative behaviors) as well the identification of key mechanisms and associated parameters with tipping points. The use of quantitative information (international indicators and statistical analyses of conflict events) allows the assessment of the plausibility of input parameter values and simulated results, and thus a better understanding of the model’s strengths and limitations.</p> <p>The contributions of the present work for understanding how mechanisms of large scale conflict lead to complex</p> <p>behavior include a new form of the estimated arrest probability, a simple representation of political vs economic deprivation with a parameter which controls the `sensitivity' to value, endogenous legitimacy feedback, and the effect of network influences (due to small groups and “activists”). In addition, the analysis of the Social Conflict Analysis Database provided a quantitative description of the impact of the “Arab Spring” in several countries focused on complexity issues such as peaceful vs violent, spontaneous vs organized, and patterns of size, duration and recurrence of conflict events in this recent and important large-scale conflict process. This book will appeal to students and researchers working in these computational social science subfields.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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6,076円
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Turning Goals into Results (Harvard Business Review Classics) The Power of Catalytic Mechanisms【電子書籍】[ Jim Collins ]
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<p>Most executives have a big, hairy, audacious goal. But they install layers of stultifying bureaucracy that prevent them from realizing it. In this article, Jim Collins introduces the <em>catalytic mechanism</em>, a simple yet powerful managerial tool that helps turn lofty aspirations into reality. The crucial link between objectives and results, this tool is a galvanizing, nonbureaucratic way to turn one into the other. But the same catalytic mechanism that works in one organization won’t necessarily work in another. So, to help readers get started, Collins offers some general principles that support the process of building one effectively.</p> <p>Since 1922, <em>Harvard Business Review</em> has been a leading source of breakthrough ideas in management practice. The <em>Harvard Business Review</em> Classics series now offers you the opportunity to make these seminal pieces a part of your permanent management library. Each highly readable volume contains a groundbreaking idea that continues to shape best practices and inspire countless managers around the world.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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510円
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Rubin's Pathology Mechanisms of Human Disease【電子書籍】[ David S. Strayer ]
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<p>With a simple approach to essential information, Rubin’s Pathology: Mechanisms of Human Disease establishes the foundation for medical training and practice and delivers the perfect balance of basic pathology and bedside perspective to confidently and efficiently equip students for clinical success. More accessible than ever, this eighth edition emphasizes the coverage students need mostーdisease mechanisms, integration of mechanisms into organ system pathology, and application of pathobiology to diagnostic medicineーin an approachable format with systems-based instruction techniques in mind. Comprehensively revised and updated content reflects the latest approaches to pathology from global leaders in the field and ensures a clinically relevant understanding of key pathology competencies.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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27,014円
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507 Mechanical Movements Mechanisms and Devices【電子書籍】[ Henry T. Brown ]
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<p>Epicyclic trains, oblique rollers, trip hammers, and lazy-tongs are among the ingenious mechanisms defined and illustrated in this intriguing collection. Spanning the first century of the Industrial Revolution, this 1868 compilation features simplified, concise illustrations of the mechanisms used in hydraulics, steam engines, pneumatics, presses, horologes, and scores of other machines.<br /> The movements of each of the 507 mechanisms are depicted in drawings on the left-hand page, and the facing page presents a brief description of the item's use and operation. Ranging from simple to intricately complex, the mechanisms offer a fascinating view of the variety of small components that constitute complex machinery. A detailed index provides easy reference to specific mechanisms.<br /> Inventors, tinkerers, and anyone with an interest in the history of invention and technology will find this volume a treasury of information and inspiration.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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716円
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March's Advanced Organic Chemistry Reactions, Mechanisms, and Structure【電子書籍】[ Michael B. Smith ]
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<p><strong>The completely revised and updated, definitive resource for students and professionals in organic chemistry</strong></p> <p>The revised and updated 8th edition of <em>March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure</em> explains the theories of organic chemistry with examples and reactions. This book is the most comprehensive resource about organic chemistry available. Readers are guided on the planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions</p> <p>The opening chapters of <em>March's Advanced Organic Chemistry, 8th Edition</em> deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Further coverage concerns general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation. The relationship between structure and reactivity is also covered. The final chapters cover the nature and scope of organic reactions and their mechanisms.</p> <p>This edition:</p> <ul> <li>Provides revised examples and citations that reflect advances in areas of organic chemistry published between 2011 and 2017</li> <li>Includes appendices on the literature of organic chemistry and the classification of reactions according to the compounds prepared</li> <li>Instructs the reader on preparing and conducting multi-step synthetic reactions, and provides complete descriptions of each reaction</li> </ul> <p>The 8th edition of <em>March's Advanced Organic Chemistry</em> proves once again that it is a must-have desktop reference and textbook for every student and professional working in organic chemistry or related fields.</p> <p><strong>Winner of the Textbook & Acadmic Authors Association 2021 McGuffey Longevity Award.</strong></p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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21,642円
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Molecular and Cellular Mechanisms of Antibody Activity【電子書籍】
楽天Kobo電子書籍ストア
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<p>This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of molecules is demonstrated by the heightened susceptibility to infections of humans and mice with an altered capacity to generate pathogen specific antibody responses. Thus, the majority of our currently available vaccines, such as vaccines against influenza, measles and hepatitis focus on the generation of long lasting antibody responses. Recent evidence from a variety of in vivo model systems and from human patient cohorts has highlighted the exclusive role of cellular Fc-receptors for certain immunoglobulin isotypes and subclasses. With the recent discovery of a human Fc-receptor for IgM all different human immunoglobulin isotypes now have a cellular receptor, providing a feedback mechanism and link between antibodies and the cellular components of the immune system. Moreover it has become clear the complement and Fc-receptor system are tightly connected and regulate each other to ensure a well balanced immune response. Among the immunoglobulin isotypes IgG plays a very important protective role against microbial infections and also as a therapeutic agent to kill tumor cells or autoantibody producing B cells in autoimmune disease. Transfer of our knowledge about the crucial function of Fc-receptors has led to the production of a second generation of therapeutic antibodies with enhanced binding to this class of receptors. Binding of antibodies to Fc-receptors leads to the recruitment of the potent pro-inflammatory effector functions of cells from the innate immune system. Hence, Fc-receptors link the innate and adaptive immune system, emphasizing the importance of both arms of the immune system and their crosstalk during anti-microbial immune responses. Besides this pro-inflammatory activity immunoglobulin G (IgG) molecules are long known to also have an anti-inflammatory function. This is demonstrated by the use of high dose intravenous immunoglobulins as a therapeutic agent in many human autoimmune diseases. During the past five years several new insights into the molecular and cellular pathways of this anti-inflammatory activity were gained radically changing our view of IgG function in vivo. Several lines of evidence suggest that the sugar moiety attached to the IgG molecule is responsible for these opposing activities and may be seen as a molecular switch enabling the immune system to change IgG function from a pro- to an anti-inflammatory activity. There is convincing evidence in mice and humans that aberrant IgG glycosylation could be an important new pathway for understanding the impaired antibody activity during autoimmune disease. Besides this tremendous increase in basic knowledge about factors influencing immunoglobulin activity the book will also provide insights into how these new insights might help to generate novel therapeutic approaches to enhance IgG activity for tumor therapy on the one hand, and how to block the self-destructive activity of IgG autoantibodies during autoimmune disease on the other hand.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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21,878円
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Reaction Mechanisms in Organic Chemistry【電子書籍】[ Metin Balc? ]
楽天Kobo電子書籍ストア
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<p><strong>An accessible and step-by-step exploration of organic reaction mechanisms</strong></p> <p>In <em>Reaction Mechanisms in Organic Chemistry,</em> eminent researcher Dr. Metin Balci delivers an excellent textbook for understanding organic reaction mechanisms. The book offers a way for undergraduate and graduate students to understand???rather than memorize???the principles of reaction mechanisms. It includes the most important reaction types, including substitution, elimination, addition, pericyclic, and C-C coupling reactions.</p> <p>Each chapter contains problems and accompanying solutions that cover central concepts in organic chemistry. Students will learn to understand the foundational nature of ideas like Lewis acids and bases, electron density, the mesomeric effect, and the inductive effect via the use of detailed examples and an expansive discussion of the concept of hybridization.</p> <p>Along with sections covering aromaticity and the chemistry of intermediates, the book includes:</p> <p>A thorough introduction to basic concepts in organic reactions, including covalent bonding, hybridization, electrophiles and nucleophiles, and inductive and mesomeric effects</p> <p>Comprehensive explorations of nucleophilic substitution reactions, including optical activity and stereochemistry of SN2 reactions</p> <p>Practical discussions of elimination reactions, including halogene elimination and Hofmann elimination</p> <p>In-depth examinations of addition reactions, including the addition of water to alkenes and the epoxidation of alkenes</p> <p>Perfect for students of chemistry, biochemistry, and pharmacy, <em>Reaction Mechanisms in Organic Chemistry</em> will also earn a place in the libraries of researchers and lecturers in these fields seeking a one-stop resource on organic reaction mechanisms.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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11,847円
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George Van Eps Harmonic Mechanisms for Guitar, Volume 3【電子書籍】[ George Van Eps ]
楽天Kobo電子書籍ストア
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<p>The most in-depth, revolutionary of the harmonic framework of music as applied to the guitar fingerboard ever presented. Leads to total mastery of harmonic and technical aspects of the guitar.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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5,063円
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Go Ahead And Die / Unhealthy Mechanisms 【CD】
HMV&BOOKS online 1号店
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出荷目安の詳細はこちら商品説明マックス・カヴァレラ(元セパルトゥラ、ソウルフライ等)と息子イゴール・アマデウス・カヴァレラによるゴー・アヘッド・アンド・ダイがアルバムをリリース!初期Celtic Frostを彷彿とさせるひたすらプリミティヴなリフと強烈な咆哮は、オールドスクール・マニアにはたまらない!Go Ahead And Dieは、あのマックス・カヴァレラ(Sepultura, Soulfly等)とその息子、イゴール・アマデウス・カヴァレラが、20年に結成したバンド。21年にリリースされたデビュー・アルバムは、「初期Celtic Frostやパンクから大きな影響を受けた、デス・メタルとスラッシュ・メタルのミックス」というバンドの理念通りの作品となり、世界中のオールドスクール・メタル・ファンに大好評を博した。そんな彼らが、2年ぶりのニュー・アルバムをリリースする。『Unhealthy Mechanisms』と題された本作でも、プリミティヴなリフにトム・G・ウォリアーばりの強烈な咆哮と、あいも変わらずオールドスクール・スピリット全開。洗練やテクニカルさとは無縁のGo Ahead And Dieワールドが繰り広げられている。Sepulturaの最初期作品をリレコーディングしたCavalera名義の作品も発表したばかりのマックスだが、やはり彼のルーツはこういうプリミティヴなオールドスクール・スタイルにあるのだろう。ミックス、マスタリングは前作に引き続きマックスが全幅の信頼を寄せる巨匠アーサー・リズク。・マックス・カヴァレラ(Sepultura、Soulfly)とその息子イゴール・アマデウス・カヴァレラによるバンド。・初期Celtic Frostを筆頭とした、オールドスクールなプリミティヴなバンドへのオマージュ。・ミックス、マスタリングはPower TripやKreatorを手がけた巨匠アーサー・リズク。日本語解説書封入/歌詞対訳付き【メンバー】マックス・カヴァレラ (ヴォーカル/ギター)イゴール・アマデウス・カヴァレラ (ヴォーカル/ギター/ベース)ジョニー・ヴァレス (ドラムス)(メーカー・インフォメーションより)曲目リストDisc11.デザート・カーネイジ/2.スプリット・スカルプ/3.テューモアズ/4.ドラッグ-オー-コップ/5.ノー・イージー・ウェイ・アウト/6.M.D.A.(モスト・デンジャラス・アニマル)/7.キャズム/8.サイバー・スレイヴァリー/9.ブラスト・ゾーン/10.アンヘルシー・メカニズムス
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2,631円
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Configurations, Dynamics and Mechanisms of Multilevel Governance【電子書籍】
楽天Kobo電子書籍ストア
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<p>This edited volume provides a comprehensive overview of the diverse and multi-faceted research on governance in multilevel systems. The book features a collection of cutting-edge trans-Atlantic contributions, covering topics such as federalism, decentralization as well as various forms and processes of regionalization and Europeanization. While the field of multilevel governance is comparatively young, research in the subject has also come of age as considerable theoretical, conceptual and empirical advances have been achieved since the first influential works were published in the early noughties. The present volume aims to gauge the state-of-the-art in the different research areas as it brings together a selection of original contributions that are united by a variety of configurations, dynamics and mechanisms related to governing in multilevel systems.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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18,231円
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Wnt Signaling in Development and Disease Molecular Mechanisms and Biological Functions【電子書籍】[ Stefan P. Hoppler ]
楽天Kobo電子書籍ストア
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<p><em>Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions</em> reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network.</p> <p>? A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field.</p> <p>? Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases</p> <p>? Reviews the complex processes of signal integration and regulation</p> <p>? Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway’s role in diseases and potential clinical applications.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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25,040円
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The Mechanisms of Perception【電子書籍】[ Jean Piaget ]
楽天Kobo電子書籍ストア
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<p>First published in 2006. This work represents an attempt to synthesise studies on the development of perception which Piaget started twenty or so years ago, when the Faculte des Sciences de Geneve appointed him to the Chair of Experimental Psychology and Director of the Psychological Laboratory. Most of the studies to be reported have already appeared in the Archives de Psychologie under the general title of Recherches sur Ie Developpement des Perceptions, however, more than fifteen studies which have not been published and which we shall deal with in the following pages.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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12,155円
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Global LGBTQ Activism Social Media, Digital Technologies, and Protest Mechanisms【電子書籍】
楽天Kobo電子書籍ストア
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<p>Focused on understanding and analyzing LGBTQ activism and protest globally, this edited collection brings together voices from different parts of the world to examine LGBTQ protests and their impact.</p> <p>Through the lens of media, culture, and sociopolitical structures, this collection highlights how cultural and technical factors like the emergence of social media and other digital platforms have impacted LGBTQ activism. This book draws on studies from countries as varied as Zimbabwe, Bangladesh, Sri Lanka, Hungary, Morocco, China, and the US. The contributions provide important insight into how social media and digital platforms have provided space for self-expression and protest and encouraged advocacy and empowerment for LGBTQ movements. It also examines the diversity and similarities between different national contexts and the various obstacles faced, while spotlighting countries that are traditionally understudied in Western academia, in an important step toward decolonizing research. Each chapter, through the voices of activists and media scholars, moves beyond an oversimplified examination of queer protests to show, in rich detail, the exciting yet complicated terrain of queer protests throughout the globe.</p> <p>This book is suitable for media, communication, and cultural studies students; researchers; academics; and LGBTQ activists, as well as students and scholars from related academic disciplines.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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8,272円
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George Van Eps Harmonic Mechanisms for Guitar, Volume 1【電子書籍】[ George Van Eps ]
楽天Kobo電子書籍ストア
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<p>The most in-depth, revolutionary presentation of the harmonic framework of music is applied to the guitar fingerboard ever presented. Leads to total mastery of harmonic and technical aspects of the guitar. The material in this landmark series of 3 massive volumes address virtually every aspect of playing jazz guitar representing the fruits of years of the author's investigation of harmony and fingerboard mobility. This series of books leads to total mastery of the harmonic and technical aspects of the guitar. In notation only.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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5,908円
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Protein Homeostasis Diseases Mechanisms and Novel Therapies【電子書籍】
楽天Kobo電子書籍ストア
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<p><em>Protein Homeostasis Diseases: Mechanisms and Novel Therapies</em> offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders.</p> <ul> <li>Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands</li> <li>Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease</li> <li>Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance</li> </ul>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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19,773円
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Ocean Dynamics and the Carbon Cycle Principles and Mechanisms【電子書籍】[ Michael J. Follows ]
楽天Kobo電子書籍ストア
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<p>This textbook for advanced undergraduate and graduate students presents a multidisciplinary approach to understanding ocean circulation and how it drives and controls marine biogeochemistry and biological productivity at a global scale. Background chapters on ocean physics, chemistry and biology provide students with the tools to examine the range of large-scale physical and dynamic phenomena that control the ocean carbon cycle and its interaction with the atmosphere. Throughout the text observational data is integrated with basic physical theory to address cutting-edge research questions in ocean biogeochemistry. Simple theoretical models, data plots and schematic illustrations summarise key results and connect the physical theory to real observations. Advanced mathematics is provided in boxes and appendices where it can be drawn on to assist with the worked examples and homework exercises available online. Further reading lists for each chapter and a comprehensive glossary provide students and instructors with a complete learning package.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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12,021円
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The Factors of Organic Evolution Unraveling the Intricate Mechanisms of Evolutionary Development and Adaptation【電子書籍】[ Herbert Spencer ]
楽天Kobo電子書籍ストア
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<p>Herbert Spencer's 'The Factors of Organic Evolution' delves into the intricate mechanisms of evolution, focusing on the diverse factors that contribute to the development and adaptation of species. The book presents a detailed analysis of natural selection, adaptation, and the role of environment in shaping the evolution of organisms. Spencer's writing style is both insightful and meticulous, providing readers with a comprehensive understanding of evolutionary concepts within a Victorian scientific context. The book is a seminal work in evolutionary theory, influencing future thinkers and biologists. Spencer's eloquent prose and logical arguments make this book a must-read for anyone interested in the complexities of evolution and the natural world. As a prolific philosopher and biologist, Spencer's thorough research and analytical approach to evolution have solidified his reputation as a key figure in the history of science and philosophy. 'The Factors of Organic Evolution' is a timeless contribution to the field of biology and a foundational text for understanding the principles of evolution.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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310円
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